2021
Genome-wide association analysis reveals regulation of at-risk loci by DNA methylation in prostate cancer
Liu Q, Liu G, Martin DT, Xing YT, Weiss RM, Qi J, Kang J. Genome-wide association analysis reveals regulation of at-risk loci by DNA methylation in prostate cancer. Asian Journal Of Andrology 2021, 23: 472-478. PMID: 33762478, PMCID: PMC8451484, DOI: 10.4103/aja.aja_20_21.Peer-Reviewed Original ResearchConceptsDNA methylationRisk lociGene expressionGenome-wide association analysisExpression quantitative trait loci (eQTL) analysisQuantitative trait locus (QTL) analysisMethylation-regulated genesEpigenetic association studiesSingle nucleotide polymorphism analysisNucleotide polymorphism analysisTranscript regulationGenomic regionsCancer Genome AtlasEpigenetic changesEpigenetic alterationsLocus analysisAssociation studiesAssociation analysisProgression of tumorsCpG sitesGenesLociMethylationGenome AtlasImportant locusDown-regulation of GP130 signaling sensitizes bladder cancer to cisplatin by impairing Ku70 DNA repair signaling and promoting apoptosis
He S, Li G, Schätzlein AG, Humphrey PA, Weiss RM, Uchegbu IF, Martin DT. Down-regulation of GP130 signaling sensitizes bladder cancer to cisplatin by impairing Ku70 DNA repair signaling and promoting apoptosis. Cellular Signalling 2021, 81: 109931. PMID: 33529758, DOI: 10.1016/j.cellsig.2021.109931.Peer-Reviewed Original ResearchConceptsBladder cancer cellsCancer cellsHuman bladder cancer specimensCisplatin-based chemotherapyBladder cancer treatmentBladder cancer specimensChemoresistant bladder cancer cellsBreast cancer cellsCell viabilityBladder cancerCancer specimensSmall molecule inhibitorsLevels of Ku70Cancer treatmentKu70 expression
2019
Glycoprotein-130 expression is associated with aggressive bladder cancer and is a potential therapeutic target
Martin DT, Shen H, Steinbach-Rankins JM, Zhu X, Johnson KK, Syed J, Saltzman WM, Weiss RM. Glycoprotein-130 expression is associated with aggressive bladder cancer and is a potential therapeutic target. Molecular Cancer Therapeutics 2019, 18: molcanther.1079.2017. PMID: 30381445, PMCID: PMC6363894, DOI: 10.1158/1535-7163.mct-17-1079.Peer-Reviewed Original ResearchConceptsBladder cancer cell linesBladder tumorsBladder cancerCancer cell linesHigh-grade bladder cancer cell linesCancer xenograft mouse modelBladder cancer growthAggressive bladder cancerPotential therapeutic targetHuman bladder tumorsXenograft mouse modelBladder cancer progressionCell linesBladder tumor cellsCurative potentialOptimal treatmentTumor gradePatient outcomesReduced cell migrationTumor volumeTumor categoryMouse modelTherapeutic targetTumor aggressivenessCancer growth
2008
Prostate expression of endothelins and their receptors in rat growth
Wada Y, Takahashi W, Latifpour J, Weiss RM, Matsumoto K, Matsui K, Yamada, Imamura T. Prostate expression of endothelins and their receptors in rat growth. Reproduction Fertility And Development 2008, 20: 750-759. PMID: 18842177, DOI: 10.1071/rd08052.Peer-Reviewed Original ResearchConceptsET-1Receptors ETAProstate growthProstate lobesET-3Role of ETAVentral prostate lobeReverse transcription-polymerase chain reactionTranscription-polymerase chain reactionMultiplex reverse transcription-polymerase chain reactionMRNA expression levelsProstate expressionEndothelinMitogenic effectProstate cellsMRNA expressionMembrane particulatesHigh expressionMonthsWeeksEnzyme 1Chain reactionExpression levelsRat growthRatsDifferential effects of diabetes induced by streptozotocin and that develops spontaneously on prostate growth in Bio Breeding (BB) rats
Yono M, Mane SM, Lin A, Weiss RM, Latifpour J. Differential effects of diabetes induced by streptozotocin and that develops spontaneously on prostate growth in Bio Breeding (BB) rats. Life Sciences 2008, 83: 192-197. PMID: 18619471, DOI: 10.1016/j.lfs.2008.06.006.Peer-Reviewed Original ResearchConceptsProstate growthMRNA expression levelsBio-BreedingDiabetic groupExpression levelsVentral prostateSTZ-diabetic ratsReal-time reverse transcription-polymerase chain reactionSTZ-induced diabeticReverse transcription-polymerase chain reactionTranscription-polymerase chain reactionMicroarray analysisHyperglycemic diabetesInitial Experience with 3% Sodium Tetradecyl Sulfate Foam and Fibered Coils for Management of Adolescent Varicocele
Reiner E, Pollak JS, Henderson KJ, Weiss RM, White RI. Initial Experience with 3% Sodium Tetradecyl Sulfate Foam and Fibered Coils for Management of Adolescent Varicocele. Journal Of Vascular And Interventional Radiology 2008, 19: 207-210. PMID: 18341950, DOI: 10.1016/j.jvir.2007.08.013.Peer-Reviewed Original ResearchConceptsInternal spermatic veinSodium tetradecyl sulfate foamSTS foamAdolescent patientsPampiniform plexusSI jointLeft internal spermatic veinRight femoral veinResults of treatmentSurgical recurrenceScrotal discomfortTesticular atrophyCollateral vesselsPhysical examinationFemoral veinSpermatic veinSacroiliac jointAdolescent varicoceleFibered coilsPatientsInitial experienceVaricoceleAdolescent subjectsDeliberate passagePlexus
2007
Regional differences in the functional and biochemical properties of endothelin receptor subtypes in the rabbit prostatic urethra
Wada Y, Takahashi W, Latifpour J, Yamada, Kai N, Honda J, Nakanishi J, Weiss RM. Regional differences in the functional and biochemical properties of endothelin receptor subtypes in the rabbit prostatic urethra. BJU International 2007, 100: 430-437. PMID: 17559559, DOI: 10.1111/j.1464-410x.2007.07064.x.Peer-Reviewed Original ResearchConceptsContractile responseET receptor subtypesMaximum contractile responseProstatic urethraReceptor subtypesET-3ET receptorsET-1High-affinity binding sitesConcentration-dependent contractile responsesSubtype specificityEndothelin receptor subtypesSmooth muscle stripsReceptor-binding techniquesRegion-specific differencesEndothelin receptorsMuscle stripsRegional differencesDistal regionUrethraSubtypesReceptorsBQ123Low affinity constantInhibition experiments
2006
Age Related Changes in the Functional, Biochemical and Molecular Properties of α1-Adrenoceptors in the Rat Genitourinary Tract
Yono M, Foster HE, Weiss RM, Latifpour J. Age Related Changes in the Functional, Biochemical and Molecular Properties of α1-Adrenoceptors in the Rat Genitourinary Tract. Journal Of Urology 2006, 176: 1214-1219. PMID: 16890728, DOI: 10.1016/j.juro.2006.04.038.Peer-Reviewed Original ResearchConceptsRat genitourinary tractLower urinary tract symptomsUrinary tract symptomsBenign prostatic hyperplasiaAdrenoceptor antagonistGenitourinary tractTract symptomsBladder baseProstatic hyperplasiaDorsolateral prostateYoung ratsIsolated muscle bathMaximum contractile responseTranscriptase-polymerase chain reaction techniqueRadioligand receptor bindingReverse transcriptase-polymerase chain reaction techniqueSignificant age-dependent differencesAge-dependent differencesAge related changesHigher body weightAge related differencesContractile responseAdrenoceptor densityAdrenoceptor subtypesBladder dome
2005
Effect of insulin treatment on tissue size of the genitourinary tract in BB rats with spontaneously developed and streptozotocin-induced diabetes
Yono M, Pouresmail M, Takahashi W, Flanagan JF, Weiss RM, Latifpour J. Effect of insulin treatment on tissue size of the genitourinary tract in BB rats with spontaneously developed and streptozotocin-induced diabetes. Naunyn-Schmiedeberg's Archives Of Pharmacology 2005, 372: 251-255. PMID: 16235050, DOI: 10.1007/s00210-005-0010-9.Peer-Reviewed Original ResearchConceptsSTZ-induced diabetesBB ratsSpontaneous diabetesGenitourinary tractInsulin treatmentDiabetes-resistant BB ratsDiabetes-prone BB ratsHyperglycemic diabetic ratsStreptozotocin-induced diabetesSerum testosterone levelsSignificant decreaseGroups of ratsEuglycemic diabeticsEuglycemic groupTissue weight changesBladder weightDiabetic ratsSuboptimal doseAdrenal glandHyperglycemic groupDiabetic studyTestosterone levelsDiabetesControl groupVentral prostateCLINICAL AND HISTOLOGICAL SIGNIFICANCE OF THE TESTICULAR REMNANT FOUND ON INGUINAL EXPLORATION AFTER DIAGNOSTIC LAPAROSCOPY IN THE ABSENCE OF A PATENT PROCESSUS VAGINALIS
RENZULLI JF, SHETTY R, MANGRAY S, ANDERSON KR, WEISS RM, CALDAMONE AA. CLINICAL AND HISTOLOGICAL SIGNIFICANCE OF THE TESTICULAR REMNANT FOUND ON INGUINAL EXPLORATION AFTER DIAGNOSTIC LAPAROSCOPY IN THE ABSENCE OF A PATENT PROCESSUS VAGINALIS. Journal Of Urology 2005, 174: 1584-1586. PMID: 16148657, DOI: 10.1097/01.ju.0000179541.92934.17.Peer-Reviewed Original ResearchConceptsGerm cell elementsPatent processus vaginalisInternal inguinal ringProcessus vaginalisClosed processus vaginalisInguinal explorationTesticular remnantsNonpalpable testisHistological findingsInguinal ringSpermatic vesselsClosed internal inguinal ringVas deferensClosed internal ringPresence of hemosiderinCell elementsDiagnostic laparoscopyLaparoscopic explorationRetrospective reviewHistological significancePatientsLeft sideCord structuresRight sideIncidence
2004
Age-Related Changes in the Properties of the Endothelin Receptor System at Protein and mRNA Levels in the Rat Vas Deferens
Yono M, Latifpour J, Takahashi W, Pouresmail M, Afiatpour P, Weiss RM. Age-Related Changes in the Properties of the Endothelin Receptor System at Protein and mRNA Levels in the Rat Vas Deferens. Journal Of Receptors And Signal Transduction 2004, 24: 53-66. PMID: 15344879, DOI: 10.1081/rrs-120034106.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsAspartic Acid EndopeptidasesDNA PrimersDown-RegulationEndothelin-1Endothelin-3Endothelin-Converting EnzymesKineticsMaleMetalloendopeptidasesPolymerase Chain ReactionProtein BindingRatsRats, Inbred F344Receptor, Endothelin AReceptor, Endothelin BReceptors, EndothelinReverse Transcriptase Polymerase Chain ReactionRNA, MessengerVas DeferensConceptsEndothelin receptor systemET receptor systemAge-related changesWeek old ratsET receptorsMonth old ratsOld ratsET-1Receptor systemVas deferensReceptor subtypesRat vasET-3MRNA levelsAge groupsFunctional ET receptorsTotal ET receptorsReceptor subtype mRNAsReal-time reverse transcription-polymerase chain reactionRadioligand receptor bindingReverse transcription-polymerase chain reactionPredominant mRNA expressionRat vas deferensTranscription-polymerase chain reactionRadioligand receptor binding assays
2003
Regulatory effect of castration on endothelins, their receptors and endothelin‐converting enzyme in rat seminal vesicle
Takahashi W, Yono M, Wada Y, Ikeda K, Weiss R, Latifpour J. Regulatory effect of castration on endothelins, their receptors and endothelin‐converting enzyme in rat seminal vesicle. BJU International 2003, 92: 803-809. PMID: 14616470, DOI: 10.1046/j.1464-410x.2003.04466.x.Peer-Reviewed Original ResearchConceptsExpression of endothelinETB receptor subtypesET receptorsECE-1 mRNARat seminal vesicleReceptor subtypesSeminal vesiclesET-1Slide-mounted frozen sectionsET receptor systemET-3 mRNATotal ET receptorsETA receptor subtypeSprague-Dawley ratsReverse transcription-polymerase chain reactionExpression levelsExpression of ETAEffects of castrationEndothelin-converting enzymeMultiplex reverse transcription-polymerase chain reactionPolymerase chain reactionSmooth muscleET-3Autoradiographic studyFrozen sectionsEffect of Intravesical Treatment of Transitional Cell Carcinoma With Bacillus Calmette-Guerin and Mitomycin C on Urinary Survivin Levels and Outcome
HAUSLADEN DA, WHEELER MA, ALTIERI DC, COLBERG JW, WEISS RM. Effect of Intravesical Treatment of Transitional Cell Carcinoma With Bacillus Calmette-Guerin and Mitomycin C on Urinary Survivin Levels and Outcome. Journal Of Urology 2003, 170: 230-234. PMID: 12796695, DOI: 10.1097/01.ju.0000063685.29339.24.Peer-Reviewed Original ResearchMeSH KeywordsAdjuvants, ImmunologicAdministration, IntravesicalAgedAged, 80 and overAntibiotics, AntineoplasticAntigens, NeoplasmBCG VaccineBiomarkers, TumorCarcinoma, Transitional CellFemaleHumansImmunoblottingInhibitor of Apoptosis ProteinsMaleMicrotubule-Associated ProteinsMiddle AgedMitomycinNeoplasm ProteinsNeoplasm Recurrence, LocalPredictive Value of TestsPrognosisSurvivinTreatment OutcomeUrinary Bladder NeoplasmsConceptsTransitional cell carcinomaCompletion of treatmentBacillus Calmette-GuerinUrinary survivin levelsSurvivin levelsTCC recurrenceCalmette-GuerinUrine survivinIntravesical treatmentIntravesical instillationCell carcinomaMitomycin CRecurrent transitional cell carcinomaPrognostic molecular markersHigher survivin levelsUrinary survivinPosttreatment valuesRecurrenceMonthsHigher likelihoodSurvivinRemissionUrineTreatmentInstillationUrinary interleukin-8 levels are elevated in subjects with transitional cell carcinoma
Sheryka E, Wheeler MA, Hausladen DA, Weiss RM. Urinary interleukin-8 levels are elevated in subjects with transitional cell carcinoma. Urology 2003, 62: 162-166. PMID: 12837459, DOI: 10.1016/s0090-4295(03)00134-1.Peer-Reviewed Original ResearchConceptsUrinary IL-8 levelsIL-8 levelsTransitional cell carcinomaBacille Calmette-GuérinIL-8Cell carcinomaCalmette-GuérinProstate cancerHealthy subjectsActive transitional cell carcinomaUrinary interleukin-8 levelsLow stage transitional cell carcinomaInterleukin-8 levelsBladder cancer cell linesBladder cancer cellsEnzyme-linked immunosorbentCancer cell linesIntravesical therapyInflammatory processInvasive tumorsAngiogenic factorsMitomycin CElevated levelsCancer cellsMitomycin C.
2002
Prostaglandin E2 Production and Cyclooxygenase-2 Induction in Human Urinary Tract Infections and Bladder Cancer
Wheeler MA, Hausladen DA, Yoon JH, Weiss RM. Prostaglandin E2 Production and Cyclooxygenase-2 Induction in Human Urinary Tract Infections and Bladder Cancer. Journal Of Urology 2002, 168: 1568-1573. PMID: 12352459, DOI: 10.1016/s0022-5347(05)64522-3.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBCG VaccineCyclooxygenase 1Cyclooxygenase 2DinoprostoneEnzyme InductionFemaleGene Expression Regulation, EnzymologicHumansIsoenzymesMaleMembrane ProteinsMiddle AgedProstaglandin-Endoperoxide SynthasesRNA, MessengerUreterUrinary BladderUrinary Bladder NeoplasmsUrinary Tract InfectionsUrogenital NeoplasmsUrotheliumConceptsUrinary prostaglandin E2 levelsUrinary tract infectionProstaglandin E2 levelsUrinary prostaglandin E2Tract infectionsBladder cancerProstaglandin E2 productionBCG treatmentCOX-2 mRNAUrogenital cancersE2 levelsUrine particulatesBladder muscleInflammatory processProstaglandin E2E2 productionBacillus Calmette-Guerin treatmentCOX-2 protein levelsCOX-2 protein expressionHuman urinary tract infectionsUrinary prostaglandin levelsCOX-2 expressionHuman bladder muscleBladder cancer casesCyclooxygenase-2 inductionQuantification of endothelins, their receptors, and endothelin-converting enzyme mRNA in rat genitourinary tract using real-time RT-PCR
Yono M, Takahashi W, Pouresmail M, Johnson DR, Foster HE, Weiss RM, Latifpour J. Quantification of endothelins, their receptors, and endothelin-converting enzyme mRNA in rat genitourinary tract using real-time RT-PCR. Journal Of Pharmacological And Toxicological Methods 2002, 48: 87-95. PMID: 14565565, DOI: 10.1016/s1056-8719(03)00022-4.Peer-Reviewed Original ResearchConceptsRat genitourinary tractGenitourinary tractET-1MRNA expressionET-3Receptor subtype mRNA expressionReceptor subtype mRNAsETA receptor subtypeReal-time reverse transcription-polymerase chain reactionSubtype mRNA expressionReverse transcription-polymerase chain reactionReceptor-mediated mechanismTranscription-polymerase chain reactionReal-time RT-PCRSubtype mRNAsPolymerase chain reactionReceptor subtypesRat bladderReal-time PCRDorsolateral prostateReceptor mRNAVentral prostateECE-1Computer-assisted programVas deferensThe effect of castration on endothelins, their receptors and endothelin converting enzyme in rat prostate
Takahashi W, Afiatpour P, Foster H, Ikeda K, Wada Y, Weiss RM, Latifpour J. The effect of castration on endothelins, their receptors and endothelin converting enzyme in rat prostate. Naunyn-Schmiedeberg's Archives Of Pharmacology 2002, 366: 166-176. PMID: 12122504, DOI: 10.1007/s00210-002-0575-5.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAspartic Acid EndopeptidasesAutoradiographyDiabetes Mellitus, ExperimentalDNA PrimersEndothelin-1Endothelin-3Endothelin-Converting EnzymesGene ExpressionMaleMetalloendopeptidasesMicroscopyOrchiectomyOrgan SizeProstateProtein BindingRadioligand AssayRatsRats, Sprague-DawleyReceptor, Endothelin AReceptor, Endothelin BReceptors, EndothelinReverse Transcriptase Polymerase Chain ReactionRNA, MessengerConceptsReceptor subtype mRNAsET receptor subtypesSerum testosterone levelsET receptorsRat prostateEffects of castrationReceptor subtypesSubtype mRNAsDorsolateral regionTestosterone levelsET-1Three-month-old SpraguePharmacological propertiesDiabetes-induced reductionET receptor systemET-3 mRNAETB receptor subtypesPost-operative dayReverse transcription-polymerase chain reactionVentral regionECE-1 mRNATranscription-polymerase chain reactionLight microscopy autoradiographyEnzyme-1 mRNAMultiplex reverse transcription-polymerase chain reaction
2001
Developmental changes in the biochemical and functional properties of endothelin receptors in rabbit renal pelvis
Wada Y, Latifpour J, Saito M, Afiatpour P, Weiss R. Developmental changes in the biochemical and functional properties of endothelin receptors in rabbit renal pelvis. BJU International 2001, 88: 950-959. PMID: 11851620, DOI: 10.1046/j.1464-4096.2001.2441.x.Peer-Reviewed Original ResearchConceptsRabbit renal pelvisTotal ET receptorsETA receptor subtypeRenal pelvisET receptorsET-1Age groupsContractile responseEndothelin receptorsPelvic regionReceptor subtypesSpontaneous activityET-1-induced contractile responseOld rabbitsDensities of ETAYoung rabbitsPresence of ETASubtype-selective compoundsReceptor-binding techniquesConcentration-dependent mannerETB subtypeEffect of ageETA receptorsETB receptorsMuscle stripsUrine Detection of Survivin and Diagnosis of Bladder Cancer
Smith SD, Wheeler MA, Plescia J, Colberg JW, Weiss RM, Altieri DC. Urine Detection of Survivin and Diagnosis of Bladder Cancer. JAMA 2001, 285: 324-328. PMID: 11176843, DOI: 10.1001/jama.285.3.324.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBiomarkers, TumorBlotting, WesternFemaleHumansInhibitor of Apoptosis ProteinsMaleMicrotubule-Associated ProteinsMiddle AgedNeoplasm ProteinsNeoplasm Recurrence, LocalPrognosisProteinsReverse Transcriptase Polymerase Chain ReactionSensitivity and SpecificityStatistics, NonparametricSurvivinUrinary Bladder NeoplasmsUrogenital NeoplasmsUrologic DiseasesConceptsRecurrent bladder cancerUrinary tract diseaseBladder cancerUrine samplesTract diseaseHealthy volunteersSurvivin levelsProstate-specific antigen levelLow-grade bladder cancerPrognostic molecular markersNoninvasive diagnostic testTranscriptase-polymerase chain reactionCommon human cancersUrine survivinGenitourinary cancersProgression of cancerAggressive diseaseAntigen levelsCervical cancerUrology clinicPolymerase chain reactionUnfavorable outcomeCystoscopy resultsRT-PCR methodSurvivin detectionRegulatory effect of experimental diabetes on the expression of endothelin receptor subtypes and their gene transcripts in the rat adrenal gland
Ikeda K, Wada Y, Sanematsu H, Foster HE, Shin D, Weiss RM, Latifpour J. Regulatory effect of experimental diabetes on the expression of endothelin receptor subtypes and their gene transcripts in the rat adrenal gland. Journal Of Endocrinology 2001, 168: 163-175. PMID: 11139780, DOI: 10.1677/joe.0.1680163.Peer-Reviewed Original ResearchConceptsEndothelin-converting enzyme-1Rat adrenal glandET receptor subtypesInduction of diabetesAdrenal glandReceptor subtypesETB receptorsExperimental diabetesAge-matched control ratsECE-1 mRNA levelsET-3 mRNAPredominant receptor subtypeDiabetes-induced changesEndothelin receptor subtypesInsulin-treated diabeticsSecretion of steroidsReceptor subtypes ETARadioligand receptor bindingAdrenal gland sizeET-1 mRNAExpression levelsRegulatory effectsVascular toneET receptorsEndothelin action