2006
A role for Akt in the rapid regulation of inflammatory and apoptotic pathways in mouse bladder
Tamarkin FJ, Kang WS, Cohen JJ, Wheeler MA, Weiss RM. A role for Akt in the rapid regulation of inflammatory and apoptotic pathways in mouse bladder. Naunyn-Schmiedeberg's Archives Of Pharmacology 2006, 373: 349-359. PMID: 16832691, DOI: 10.1007/s00210-006-0081-2.Peer-Reviewed Original ResearchConceptsApoptotic pathwayPI3KAkt phosphorylationNon-phosphorylated speciesPhosphatidylinositol-3 kinaseNF-κBPhosphorylation of AktPI3K/AktCellular signalingTranscription factorsForkhead familyPI3K inhibitorsNF-κB phosphorylationKappa BDownstream pathwaysAkt activationInhibitor kappa BPhosphorylationRapid regulationAktProtein amountNuclear factor kappa BK inhibitorsCancer cellsUrothelial cancer cells
2004
Rapid Up-Regulation of Endothelial Nitric-Oxide Synthase in a Mouse Model of Escherichia coli Lipopolysaccharide-Induced Bladder Inflammation
Kang WS, Tamarkin FJ, Wheeler MA, Weiss RM. Rapid Up-Regulation of Endothelial Nitric-Oxide Synthase in a Mouse Model of Escherichia coli Lipopolysaccharide-Induced Bladder Inflammation. Journal Of Pharmacology And Experimental Therapeutics 2004, 310: 452-458. PMID: 15082754, DOI: 10.1124/jpet.104.066506.Peer-Reviewed Original ResearchConceptsInducible nitric oxide synthaseUrinary cyclic GMPNitric oxide synthaseEscherichia coli lipopolysaccharideLPS treatmentNOS activityColi lipopolysaccharideNitric oxideEndothelial nitric oxide synthaseDependent NOS activityCyclic GMPInduction of inflammationPhosphorylation of eNOSBladder inflammationLPS injectionHuman eNOSENOS proteinIntraperitoneal injectionFemale miceBladder urotheliumInflammatory responseMolecule nitric oxideMouse modelInflammationENOS phosphorylation