2021
Genome-wide association analysis reveals regulation of at-risk loci by DNA methylation in prostate cancer
Liu Q, Liu G, Martin DT, Xing YT, Weiss RM, Qi J, Kang J. Genome-wide association analysis reveals regulation of at-risk loci by DNA methylation in prostate cancer. Asian Journal Of Andrology 2021, 23: 472-478. PMID: 33762478, PMCID: PMC8451484, DOI: 10.4103/aja.aja_20_21.Peer-Reviewed Original ResearchConceptsDNA methylationRisk lociGene expressionGenome-wide association analysisExpression quantitative trait loci (eQTL) analysisQuantitative trait locus (QTL) analysisMethylation-regulated genesEpigenetic association studiesSingle nucleotide polymorphism analysisNucleotide polymorphism analysisTranscript regulationGenomic regionsCancer Genome AtlasEpigenetic changesEpigenetic alterationsLocus analysisAssociation studiesAssociation analysisProgression of tumorsCpG sitesGenesLociMethylationGenome AtlasImportant locus
2003
Effect of Intravesical Treatment of Transitional Cell Carcinoma With Bacillus Calmette-Guerin and Mitomycin C on Urinary Survivin Levels and Outcome
HAUSLADEN DA, WHEELER MA, ALTIERI DC, COLBERG JW, WEISS RM. Effect of Intravesical Treatment of Transitional Cell Carcinoma With Bacillus Calmette-Guerin and Mitomycin C on Urinary Survivin Levels and Outcome. Journal Of Urology 2003, 170: 230-234. PMID: 12796695, DOI: 10.1097/01.ju.0000063685.29339.24.Peer-Reviewed Original ResearchMeSH KeywordsAdjuvants, ImmunologicAdministration, IntravesicalAgedAged, 80 and overAntibiotics, AntineoplasticAntigens, NeoplasmBCG VaccineBiomarkers, TumorCarcinoma, Transitional CellFemaleHumansImmunoblottingInhibitor of Apoptosis ProteinsMaleMicrotubule-Associated ProteinsMiddle AgedMitomycinNeoplasm ProteinsNeoplasm Recurrence, LocalPredictive Value of TestsPrognosisSurvivinTreatment OutcomeUrinary Bladder NeoplasmsConceptsTransitional cell carcinomaCompletion of treatmentBacillus Calmette-GuerinUrinary survivin levelsSurvivin levelsTCC recurrenceCalmette-GuerinUrine survivinIntravesical treatmentIntravesical instillationCell carcinomaMitomycin CRecurrent transitional cell carcinomaPrognostic molecular markersHigher survivin levelsUrinary survivinPosttreatment valuesRecurrenceMonthsHigher likelihoodSurvivinRemissionUrineTreatmentInstillationUrinary interleukin-8 levels are elevated in subjects with transitional cell carcinoma
Sheryka E, Wheeler MA, Hausladen DA, Weiss RM. Urinary interleukin-8 levels are elevated in subjects with transitional cell carcinoma. Urology 2003, 62: 162-166. PMID: 12837459, DOI: 10.1016/s0090-4295(03)00134-1.Peer-Reviewed Original ResearchConceptsUrinary IL-8 levelsIL-8 levelsTransitional cell carcinomaBacille Calmette-GuérinIL-8Cell carcinomaCalmette-GuérinProstate cancerHealthy subjectsActive transitional cell carcinomaUrinary interleukin-8 levelsLow stage transitional cell carcinomaInterleukin-8 levelsBladder cancer cell linesBladder cancer cellsEnzyme-linked immunosorbentCancer cell linesIntravesical therapyInflammatory processInvasive tumorsAngiogenic factorsMitomycin CElevated levelsCancer cellsMitomycin C.
2002
Prostaglandin E2 Production and Cyclooxygenase-2 Induction in Human Urinary Tract Infections and Bladder Cancer
Wheeler MA, Hausladen DA, Yoon JH, Weiss RM. Prostaglandin E2 Production and Cyclooxygenase-2 Induction in Human Urinary Tract Infections and Bladder Cancer. Journal Of Urology 2002, 168: 1568-1573. PMID: 12352459, DOI: 10.1016/s0022-5347(05)64522-3.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBCG VaccineCyclooxygenase 1Cyclooxygenase 2DinoprostoneEnzyme InductionFemaleGene Expression Regulation, EnzymologicHumansIsoenzymesMaleMembrane ProteinsMiddle AgedProstaglandin-Endoperoxide SynthasesRNA, MessengerUreterUrinary BladderUrinary Bladder NeoplasmsUrinary Tract InfectionsUrogenital NeoplasmsUrotheliumConceptsUrinary prostaglandin E2 levelsUrinary tract infectionProstaglandin E2 levelsUrinary prostaglandin E2Tract infectionsBladder cancerProstaglandin E2 productionBCG treatmentCOX-2 mRNAUrogenital cancersE2 levelsUrine particulatesBladder muscleInflammatory processProstaglandin E2E2 productionBacillus Calmette-Guerin treatmentCOX-2 protein levelsCOX-2 protein expressionHuman urinary tract infectionsUrinary prostaglandin levelsCOX-2 expressionHuman bladder muscleBladder cancer casesCyclooxygenase-2 induction
2001
Urine Detection of Survivin and Diagnosis of Bladder Cancer
Smith SD, Wheeler MA, Plescia J, Colberg JW, Weiss RM, Altieri DC. Urine Detection of Survivin and Diagnosis of Bladder Cancer. JAMA 2001, 285: 324-328. PMID: 11176843, DOI: 10.1001/jama.285.3.324.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBiomarkers, TumorBlotting, WesternFemaleHumansInhibitor of Apoptosis ProteinsMaleMicrotubule-Associated ProteinsMiddle AgedNeoplasm ProteinsNeoplasm Recurrence, LocalPrognosisProteinsReverse Transcriptase Polymerase Chain ReactionSensitivity and SpecificityStatistics, NonparametricSurvivinUrinary Bladder NeoplasmsUrogenital NeoplasmsUrologic DiseasesConceptsRecurrent bladder cancerUrinary tract diseaseBladder cancerUrine samplesTract diseaseHealthy volunteersSurvivin levelsProstate-specific antigen levelLow-grade bladder cancerPrognostic molecular markersNoninvasive diagnostic testTranscriptase-polymerase chain reactionCommon human cancersUrine survivinGenitourinary cancersProgression of cancerAggressive diseaseAntigen levelsCervical cancerUrology clinicPolymerase chain reactionUnfavorable outcomeCystoscopy resultsRT-PCR methodSurvivin detection
2000
Temporal changes of cytokines and nitric oxide products in urine from renal transplant patients
Smith S, Wheeler M, Lorber M, Weiss R. Temporal changes of cytokines and nitric oxide products in urine from renal transplant patients. Kidney International 2000, 58: 829-837. PMID: 10916108, DOI: 10.1046/j.1523-1755.2000.00232.x.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdultCreatinineCyclic GMPCytokinesFemaleFollow-Up StudiesGraft RejectionHumansInterleukin-10Interleukin-2Interleukin-6Interleukin-8Kidney Failure, ChronicKidney TransplantationMaleMiddle AgedNitratesNitric OxideNitritesPredictive Value of TestsTime FactorsTumor Necrosis Factor-alphaUrinary Tract InfectionsConceptsUrinary tract infectionRenal transplant patientsAcute rejectionTransplant patientsCyclic GMPIL-2Nitric oxideNitric oxide synthase activityAdditional urine specimensUrine cytokine levelsUrine nitrate levelsNitric oxide productsMonths of transplantationOxide synthase activityUrine nitrateSoluble interleukinCytokine levelsTract infectionsIL-10IL-6IL-8Tumor necrosisUrine specimensPatientsClinical diagnosis
1999
Tumor Content of the Antiapoptosis Molecule Survivin and Recurrence of Bladder Cancer
Swana H, Grossman D, Anthony J, Weiss R, Altieri D. Tumor Content of the Antiapoptosis Molecule Survivin and Recurrence of Bladder Cancer. New England Journal Of Medicine 1999, 341: 452-453. PMID: 10438269, DOI: 10.1056/nejm199908053410614.Peer-Reviewed Original ResearchAgedApoptosisBiomarkers, TumorCarcinoma, Transitional CellDisease ProgressionFemaleHumansInhibitor of Apoptosis ProteinsMaleMicrotubule-Associated ProteinsMiddle AgedNeoplasm ProteinsNeoplasm Recurrence, LocalProteinsProto-Oncogene Proteins c-bcl-2SurvivinTumor Suppressor Protein p53Urinary Bladder NeoplasmsA RANDOMIZED DOUBLE-BLIND TRIAL OF ORAL L-ARGININE FOR TREATMENT OF INTERSTITIAL CYSTITIS
KORTING G, SMITH S, WHEELER M, WEISS R, FOSTER H. A RANDOMIZED DOUBLE-BLIND TRIAL OF ORAL L-ARGININE FOR TREATMENT OF INTERSTITIAL CYSTITIS. Journal Of Urology 1999, 161: 558-565. PMID: 9915448, DOI: 10.1016/s0022-5347(01)61950-5.Peer-Reviewed Original ResearchConceptsL-arginine groupOral L-arginineNitric oxide synthase activityInterstitial cystitis symptomsInterstitial cystitis patientsOxide synthase activityPlacebo groupInterstitial cystitisL-arginineCystitis symptomsCystitis patientsUrinary nitric oxide synthase activityRandomized double-blind trialDouble-blind trialFrequency of painL-arginine treatmentGreater global improvementNitric oxide synthaseUrine of patientsUrine of controlsPain intensityOxide synthaseSynthase activityGlobal improvementPatients
1998
Detection of urinary tract infections by reduction of nitroblue tetrazolium Technical Note
Smith S, Wheeler M, Weiss R. Detection of urinary tract infections by reduction of nitroblue tetrazolium Technical Note. Kidney International 1998, 54: 1331-1336. PMID: 9767552, DOI: 10.1046/j.1523-1755.1998.00102.x.Peer-Reviewed Original ResearchConceptsUrinary tract infectionNitric oxide synthaseNegative predictive accuracyDismutase/catalaseNitrite dipstickTract infectionsPresence of UTINOS cofactorUrine pelletsInducible nitric oxide synthaseHigh negative predictive accuracyHigh positive predictive accuracyUrine screening testsUrine culture resultsNBT reductionInducible NOS activityLeukocyte esterase dipstickNitroblue tetrazolium reductionPositive predictive accuracyNOS inhibitorNOS activityOxide synthaseEarly predictorCulture resultsScreening test
1997
Improvement in Interstitial Cystitis Symptom Scores During Treatment With Oral L-Arginine
Smith S, Wheeler M, Foster H, Weiss R. Improvement in Interstitial Cystitis Symptom Scores During Treatment With Oral L-Arginine. Journal Of Urology 1997, 158: 703-708. DOI: 10.1016/s0022-5347(01)64297-6.Peer-Reviewed Original ResearchConceptsOral L-arginineL-arginineInterstitial cystitisInterstitial Cystitis Symptom ScoreNitric oxide synthase activityLower abdominal painInterstitial cystitis symptomsL-arginine treatmentOxide synthase activityNitric oxide synthaseSelf-controlled studyAbdominal painUrethral painUrinary frequencyCystitis symptomsSymptom scoresMethodsTen patientsOxide synthaseRelated symptomsImmunological responseNitric oxidePatientsSymptomsSignificant decreaseCystitisImprovement in Interstitial Cystitis Symptom Scores During Treatment With Oral L-Arginine
Smith S, Wheeler M, Foster H, Weiss R. Improvement in Interstitial Cystitis Symptom Scores During Treatment With Oral L-Arginine. Journal Of Urology 1997, 158: 703-708.. PMID: 9258064, DOI: 10.1097/00005392-199709000-00005.Peer-Reviewed Original ResearchConceptsOral L-arginineL-arginineInterstitial cystitisUrinary nitric oxide synthase activityInterstitial Cystitis Symptom ScoreOral L-arginine treatmentNitric oxide synthase activityLower abdominal painInterstitial cystitis symptomsMethods Ten patientsL-arginine treatmentOxide synthase activityNitric oxide synthaseSelf-controlled studyAbdominal painTEN patientsUrethral painUrinary frequencyCystitis symptomsSymptom scoresOxide synthaseRelated symptomsImmunological responseNitric oxidePatientsBacterial infection induces nitric oxide synthase in human neutrophils.
Wheeler MA, Smith SD, García-Cardeña G, Nathan CF, Weiss RM, Sessa WC. Bacterial infection induces nitric oxide synthase in human neutrophils. Journal Of Clinical Investigation 1997, 99: 110-116. PMID: 9011564, PMCID: PMC507774, DOI: 10.1172/jci119121.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnti-Bacterial AgentsArginineBacterial InfectionsBlotting, WesternCanavanineCell MembraneCitrullineFemaleGuanidinesHumansImmunohistochemistryIsoenzymesLeukocyte Common AntigensMaleMiddle AgedNeutrophilsNG-Nitroarginine Methyl EsterNitric Oxide SynthaseNitroarginineOmega-N-MethylarginineOrnithinePolymerase Chain ReactionRNA, MessengerSulfonamidesThioureaTrifluoperazineUrinary Tract InfectionsConceptsInducible nitric oxide synthaseUrinary tract infectionNitric oxide synthaseNitric oxide synthase activityTract infectionsOxide synthase activityOxide synthaseInducible nitric oxide synthase activityNitric oxide synthase proteinNitric oxide synthase isoformsInduces nitric oxide synthaseMajor nitric oxide synthase isoformHuman inflammatory cellsHuman inducible nitric oxide synthaseExtended elevationInflammatory cellsProinflammatory functionsAntibiotic treatmentInflammatory processSynthase activityImmunocytochemical evidenceHuman neutrophilsInfectionCalcium independentSynthase isoforms
1996
Nitric oxide synthase induction with renal transplant rejection or infection
Smith S, Wheeler M, Zhang R, Weiss E, Lorber M, Sessa W, Weiss R. Nitric oxide synthase induction with renal transplant rejection or infection. Kidney International 1996, 50: 2088-2093. PMID: 8943494, DOI: 10.1038/ki.1996.533.Peer-Reviewed Original ResearchConceptsUrinary tract infectionRenal transplant patientsNitric oxide synthaseCyclic GMP levelsTransplant patientsTract infectionsNOS activityPost-renal transplantation patientsGMP levelsInducible nitric oxide synthaseNitric oxideRenal allograft rejectionRenal transplant rejectionNitric oxide synthase inductionInducible NOS (iNOS) mRNAUrine of patientsRenal transplantationTransplantation patientsAllograft rejectionTransplant rejectionInducible NOSOxide synthaseNOS mRNAPatientsSynthase inductionUrinary Nitric Oxide Synthase Activity and Cyclic GMP Levels are Decreased with Interstitial Cystitis and Increased with Urinary Tract Infections
Smith S, Wheeler M, Foster H, Weiss R. Urinary Nitric Oxide Synthase Activity and Cyclic GMP Levels are Decreased with Interstitial Cystitis and Increased with Urinary Tract Infections. Journal Of Urology 1996, 155: 1432-1435. PMID: 8632605, DOI: 10.1016/s0022-5347(01)66301-8.Peer-Reviewed Original ResearchConceptsUrinary tract infectionCyclic GMP levelsUrinary nitric oxide synthase activityNitric oxide synthase activityInterstitial cystitisOxide synthase activityFemale patientsNOS activityTract infectionsGMP levelsFemale controlsFemale urinary tract infectionCyclic GMP/Certain disease processesIC patientsImmunologic responseUrinary tractSynthase activityDisease processL-argininePatientsNitric oxideL-citrullineGuanylyl cyclaseCyclic GMP
1987
Complications of Ureteral Endoscopy
Lytton B, Weiss R, Green D. Complications of Ureteral Endoscopy. Journal Of Urology 1987, 137: 649-653. PMID: 3550147, DOI: 10.1016/s0022-5347(17)44165-6.Peer-Reviewed Original ResearchConceptsUreteral perforationUpper ureteral stonesVariety of indicationsIleal replacementMinor complicationsMajor complicationsUreteral lesionsUrinary extravasationAseptic necrosisSurgical correctionIntramural ureterUreteral endoscopyUreteral stonesBasket extractionUreteral calculiComplicationsUreteroscopic proceduresUreterPerforationRigid ureterorenoscopeIleusMorbidityUrinomaPainMarsupialization
1979
Results of Biopsy After Early Stage Prostatic Cancer Treatment by Implantation of 125I Seeds
Lytton B, Collins J, Weiss R, Schiff M, Mcguire E, Livolsi V. Results of Biopsy After Early Stage Prostatic Cancer Treatment by Implantation of 125I Seeds. Journal Of Urology 1979, 121: 306-309. PMID: 430623, DOI: 10.1016/s0022-5347(17)56764-6.Peer-Reviewed Original ResearchConceptsPersistent tumorProstatic cancer treatmentPelvic lymph nodesSigns of progressionStage of diseaseResults of biopsyEarly stage carcinomaProgression of diseaseBony metastasesPatients 14Metastatic diseasePelvic lymphadenectomyLymph nodesPostoperative biopsiesSecond biopsyNegative biopsyStage carcinomaHistological evidenceNeedle biopsyStage A2BiopsyStage CStage BCytoplasmic vacuolationMinimum dose
1976
Urologic Complications of Inflammatory Bowel Disease
Shield D, Lytton B, Weiss R, Schiff M. Urologic Complications of Inflammatory Bowel Disease. Journal Of Urology 1976, 115: 701-706. PMID: 940206, DOI: 10.1016/s0022-5347(17)59341-6.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseBowel diseaseUrologic complicationsPrimary bowel diseaseUrinary tract complicationsLong-term managementEnterovesical fistulaUrologic evaluationGastrointestinal disordersUreteral obstructionComplicationsDiseaseUrinary calculiPatientsCommon problemFistulaObstructionSymptoms
1975
Palliative Urinary Diversion for Pelvic Malignancy
Brin E, Schiff M, Weiss R. Palliative Urinary Diversion for Pelvic Malignancy. Journal Of Urology 1975, 113: 619-622. PMID: 47918, DOI: 10.1016/s0022-5347(17)59536-1.Peer-Reviewed Original Research
1974
Hemorrhagic radiation cystitis Treatment
McGuire E, Weiss R, Schiff M, Lytton B. Hemorrhagic radiation cystitis Treatment. Urology 1974, 3: 204-208. PMID: 4812667, DOI: 10.1016/s0090-4295(74)80016-6.Peer-Reviewed Original Research
1973
Acute urinary retention following renal transplantation
Schiff M, Weiss R, Kraus P, Lytton B. Acute urinary retention following renal transplantation. Urology 1973, 1: 108-110. PMID: 4129500, DOI: 10.1016/0090-4295(73)90593-1.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAzathioprineBlood Urea NitrogenDiuresisGraft RejectionHumansKidney Failure, ChronicKidney TransplantationMaleMiddle AgedPostoperative ComplicationsPrednisoneProstatectomyProstatic HyperplasiaRenal DialysisTransplantation, HomologousUrinary BladderUrinary Bladder Neck ObstructionUrinary DiversionUrination DisordersConceptsAcute urinary retentionUrinary retentionRenal transplantationThorough urologic evaluationRenal transplant recipientsBenign prostatic hypertrophyTemporary urinary diversionTransplant recipientsUrologic evaluationSuprapubic cystostomyUrinary diversionProstatic hypertrophyTransplantationCystostomyPatientsProstatectomyHypertrophyRecipients