A DNA enzyme that cleaves RNA
Breaker R, Joyce G. A DNA enzyme that cleaves RNA. Cell Chemical Biology 1994, 1: 223-229. PMID: 9383394, DOI: 10.1016/1074-5521(94)90014-0.Peer-Reviewed Original ResearchConceptsDNA enzymeRNA enzymeDependent cleavageSimilarity of DNATypes of RNACatalytic domainDNA sequencesRandom nucleotidesRapid turnoverRNASuccessive roundsEnzymeDNACatalytic rateSelective amplificationBiological systemsTurnover rateSequenceCleavageIntermolecular contextNucleotidesPopulationTurnoverPhosphoestersEmergence of a replicating species from an in vitro RNA evolution reaction.
Breaker R, Joyce G. Emergence of a replicating species from an in vitro RNA evolution reaction. Proceedings Of The National Academy Of Sciences Of The United States Of America 1994, 91: 6093-6097. PMID: 7517040, PMCID: PMC44144, DOI: 10.1073/pnas.91.13.6093.Peer-Reviewed Original ResearchConceptsRNA polymeraseDNA-dependent RNA polymeraseRNA polymerase promoter sequencePromoter sequencesEvolution experimentsRNA moleculesAcid sequenceRNA transcriptsSpecific nucleic acid sequencesTarget chemical reactionNucleic acid sequencesRNA replicationPolymeraseRNADNAReverse transcriptaseSelective amplificationDNA hairpinsSequence replicationChemical reactionsUnique classReplicationSequenceTranscriptaseParticular chemical reaction