1999
Relationship between internucleotide linkage geometry and the stability of RNA.
Soukup G, Breaker R. Relationship between internucleotide linkage geometry and the stability of RNA. RNA 1999, 5: 1308-25. PMID: 10573122, PMCID: PMC1369853, DOI: 10.1017/s1355838299990891.Peer-Reviewed Original Research
1997
Rational design of allosteric ribozymes
Tang J, Breaker R. Rational design of allosteric ribozymes. Cell Chemical Biology 1997, 4: 453-459. PMID: 9224568, DOI: 10.1016/s1074-5521(97)90197-6.Peer-Reviewed Original ResearchConceptsAllosteric regulationAllosteric ribozymesEffector moleculesProtein enzymesActive siteCatalytic ratePresence of dATPSelf-cleaving ribozymesSmall effector moleculesPresence of ATPSmall molecule receptorRational design strategyCellular processesEnzyme active siteAptamer domainAllosteric controlAllosteric enzymeCatalytic RNARNA aptamersConformational changesLigand moleculesMetabolic pathwaysCatalytic activityAllosteric hammerheadCatalytic features