2023
Secretory MPP3 reinforce myeloid differentiation trajectory and amplify myeloid cell production
Kang Y, Paik H, Zhang S, Chen J, Olson O, Mitchell C, Collins A, Swann J, Warr M, Fan R, Passegué E. Secretory MPP3 reinforce myeloid differentiation trajectory and amplify myeloid cell production. Journal Of Experimental Medicine 2023, 220: e20230088. PMID: 37115584, PMCID: PMC10140385, DOI: 10.1084/jem.20230088.Peer-Reviewed Original ResearchConceptsGranulocyte/macrophage progenitorsHematopoietic stem cellsMyeloid differentiationMajor functional contributorsNovel regulatory functionLocal bone marrow (BM) microenvironmentSteady-state hematopoiesisDifferentiation trajectoriesRecent lineagesMyeloid cell productionCellular heterogeneityBone marrow microenvironmentRegulatory functionsFunctional contributorsMacrophage progenitorsSecretory cellsStem cellsMPP3Blood productionMarrow microenvironmentCell productionDifferentiationRapid productionDistinct subsetsMyelopoiesis
2021
3018 – SECRETORY MPP3 ENFORCE MYELOID DIFFERENTIATION TRAJECTORY AND AMPLIFY MYELOID CELL PRODUCTION
Kang Y, Paik H, Zhang S, Chen J, Warr M, Fan R, Passegué E. 3018 – SECRETORY MPP3 ENFORCE MYELOID DIFFERENTIATION TRAJECTORY AND AMPLIFY MYELOID CELL PRODUCTION. Experimental Hematology 2021, 100: s52. DOI: 10.1016/j.exphem.2021.12.240.Peer-Reviewed Original ResearchMyeloid cell productionBA miceMyeloid differentiationCell productionDonor chimerismSurvival benefitCytokine productionMolecular subsetsInflammatory stimuliMouse modelSpecific cytokinesMyeloid malignanciesMyeloproliferative neoplasmsDifferentiation cytokinesImmature cellsGalectin-3Disease conditionsMetabolic activationColony formationAberrant functionCytokinesConstitutive secretionMiceER volumeBlood production