Increased Interleukin-8 (IL8)-CXCR2 Signaling Promotes Progression of Bone Marrow Fibrosis in Myeloproliferative Neoplasms
Dunbar A, Lu M, Farina M, Park Y, Yang J, Kim D, Karzai A, Salama M, Snyder J, Krishnan A, Koche R, Fan R, Levine R, Hoffman R. Increased Interleukin-8 (IL8)-CXCR2 Signaling Promotes Progression of Bone Marrow Fibrosis in Myeloproliferative Neoplasms. Blood 2020, 136: 6-7. DOI: 10.1182/blood-2020-138843.Peer-Reviewed Original ResearchCurrent equity holderMF patientsInterleukin-8Overall survivalReticulin fibrosisMyeloproliferative neoplasmsMF CD34Recipient miceCytokine assaysMPN patientsBone marrowPro-inflammatory cytokine interleukin-8IL8 expressionElevated pro-inflammatory cytokinesPV/ET patientsAdvisory CommitteeWT recipient miceLarger spleen sizePro-inflammatory cytokinesPro-inflammatory pathwaysBone marrow fibrosisS100A8/A9Hallmark featureCytokine interleukin-8Enhanced surface expression