2023
Anti-seed PNAs targeting multiple oncomiRs for brain tumor therapy
Wang Y, Malik S, Suh H, Xiao Y, Deng Y, Fan R, Huttner A, Bindra R, Singh V, Saltzman W, Bahal R. Anti-seed PNAs targeting multiple oncomiRs for brain tumor therapy. Science Advances 2023, 9: eabq7459. PMID: 36753549, PMCID: PMC9908025, DOI: 10.1126/sciadv.abq7459.Peer-Reviewed Original ResearchConceptsConvection-enhanced deliveryHigh recurrence rateOrthotopic mouse modelBrain tumor therapyTreatment of glioblastomaRecurrence ratePoor survivalLethal malignancyMouse modelGBM progressionTumor cellsGlioblastomaTumor therapyBioadhesive nanoparticlesOncomiRSurvivalTreatmentSeed regionMalignancyTemozolomideTherapy
2021
3018 – SECRETORY MPP3 ENFORCE MYELOID DIFFERENTIATION TRAJECTORY AND AMPLIFY MYELOID CELL PRODUCTION
Kang Y, Paik H, Zhang S, Chen J, Warr M, Fan R, Passegué E. 3018 – SECRETORY MPP3 ENFORCE MYELOID DIFFERENTIATION TRAJECTORY AND AMPLIFY MYELOID CELL PRODUCTION. Experimental Hematology 2021, 100: s52. DOI: 10.1016/j.exphem.2021.12.240.Peer-Reviewed Original ResearchMyeloid cell productionBA miceMyeloid differentiationCell productionDonor chimerismSurvival benefitCytokine productionMolecular subsetsInflammatory stimuliMouse modelSpecific cytokinesMyeloid malignanciesMyeloproliferative neoplasmsDifferentiation cytokinesImmature cellsGalectin-3Disease conditionsMetabolic activationColony formationAberrant functionCytokinesConstitutive secretionMiceER volumeBlood production