2012
Design of a Phase III Clinical Trial with Prospective Biomarker Validation: SWOG S0819
Redman MW, Crowley JJ, Herbst RS, Hirsch FR, Gandara DR. Design of a Phase III Clinical Trial with Prospective Biomarker Validation: SWOG S0819. Clinical Cancer Research 2012, 18: 4004-4012. PMID: 22592956, PMCID: PMC3409929, DOI: 10.1158/1078-0432.ccr-12-0167.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedAntineoplastic AgentsBiomarkers, TumorCarcinoma, Non-Small-Cell LungCetuximabClinical Trials, Phase III as TopicDisease-Free SurvivalErbB ReceptorsHumansIn Situ Hybridization, FluorescenceLung NeoplasmsPrognosisProspective StudiesResearch DesignTreatment OutcomeConceptsNon-small cell lung cancerEpidermal growth factor receptorPredictive biomarkersStudy populationAdvanced non-small cell lung cancerEGFR FISH-positive patientsPhase III clinical trialsRole of cetuximabOverall study populationPhase III trialsCell lung cancerEntire study populationFISH-positive patientsInterim monitoring planGrowth factor receptorCoprimary endpointsIII trialsCetuximab efficacyLung cancerClinical trialsPositive groupCetuximabEGFR FISHFactor receptorMolecular targets
2011
Imaging and Molecular Markers for Patients with Lung Cancer: Approaches with Molecular Targets, Complementary/Innovative Treatment, and Therapeutic Modalities
Hong W, Herbst R. Imaging and Molecular Markers for Patients with Lung Cancer: Approaches with Molecular Targets, Complementary/Innovative Treatment, and Therapeutic Modalities. 2011 DOI: 10.21236/ada548594.Peer-Reviewed Original ResearchRaf/MEK/ERK pathwayMEK/ERK pathwayRas/Raf/MEK/ERK pathwayLung cancerTherapeutic modalitiesNSCLC pathogenesisEGFR pathwayInnovative treatmentsMolecular targetsERK pathwaySignal transduction pathwaysImaging techniquesModalitiesPathwayTransduction pathwaysPeptide approachPatientsPathogenesisCancerReceptors
2009
Summary of Selected Presentations from the 8th Annual Targeted Therapy in Lung Cancer Symposium
Camidge R, Gaspar L, Goss G, Kelly K, Ramalingam S, Reckamp K, Simon G, Tsao M, West H, Herbst R, Johnson D, Bunn P, Govindan R. Summary of Selected Presentations from the 8th Annual Targeted Therapy in Lung Cancer Symposium. Journal Of Thoracic Oncology 2009, 4: 930-935. PMID: 19550249, DOI: 10.1097/jto.0b013e3181a9a03b.Peer-Reviewed Original ResearchConceptsLung cancerTargeted therapyGastrointestinal stromal tumorsCancer-related deathChronic myeloid leukemiaCancer SymposiumCytotoxic chemotherapyStromal tumorsMyeloid leukemiaBreast cancerCancerTherapyMolecular targetsCancer therapyTreatmentStriking improvementConsiderable optimismAnnual MeetingCancer genomicsChemotherapyInternational AssociationPatientsLeukemiaTumorsYears