Tumor Blood Flow Measured by PET Dynamic Imaging of First-Pass 18F-FDG Uptake: A Comparison with 15O-Labeled Water-Measured Blood Flow
Mullani NA, Herbst RS, O'Neil RG, Gould KL, Barron BJ, Abbruzzese JL. Tumor Blood Flow Measured by PET Dynamic Imaging of First-Pass 18F-FDG Uptake: A Comparison with 15O-Labeled Water-Measured Blood Flow. Journal Of Nuclear Medicine 2008, 49: 517-523. PMID: 18344436, DOI: 10.2967/jnumed.107.048504.Peer-Reviewed Original ResearchConceptsBlood flowUptake scanPET scansControl ROIMore tumor sitesFirst-pass uptakeTumor blood flowEarly uptakeRegional blood flowNovel antiangiogenic agentsArterial blood concentrationDose-escalating protocolPET molecular imagingMeasured blood flowPerfusion scanEstimate of perfusionBlood concentrationsBolus injectionProstate cancerAntiangiogenic agentsTumor perfusionGlucose metabolismBlood flow analysisBack musclesLarge arteries