2011
Evaluation of pharmacodynamic biomarkers in a Phase 1a trial of dulanermin (rhApo2L/TRAIL) in patients with advanced tumours
Pan Y, Xu R, Peach M, Huang CP, Branstetter D, Novotny W, Herbst RS, Eckhardt SG, Holland PM. Evaluation of pharmacodynamic biomarkers in a Phase 1a trial of dulanermin (rhApo2L/TRAIL) in patients with advanced tumours. British Journal Of Cancer 2011, 105: 1830-1838. PMID: 22033270, PMCID: PMC3251880, DOI: 10.1038/bjc.2011.456.Peer-Reviewed Original ResearchConceptsCell death markersAdvanced tumorsPharmacodynamic biomarkersApoptotic markersPhase 1a studyPhase 1a trialDeath receptors DR4Colo205 tumorsSerum 8Patients 24Active caspase-3Patient seraColo205 xenograftsEvidence of activitySubsequent cell deathCytokeratin 18PatientsTransient increaseDulanerminReceptors DR4TumorsCaspase-3SerumCaspase-3/7Significant increase
1991
Differential regulation of hepatocyte-enriched transcription factors explains changes in albumin and transthyretin gene expression among hepatoma cells.
Herbst RS, Nielsch U, Sladek F, Lai E, Babiss LE, Darnell JE. Differential regulation of hepatocyte-enriched transcription factors explains changes in albumin and transthyretin gene expression among hepatoma cells. The New Biologist 1991, 3: 289-96. PMID: 1878351.Peer-Reviewed Original ResearchMeSH KeywordsAlbuminsAnimalsBase SequenceCCAAT-Enhancer-Binding ProteinsDNADNA-Binding ProteinsGene Expression RegulationHepatocyte Nuclear Factor 1Hepatocyte Nuclear Factor 1-alphaHepatocyte Nuclear Factor 1-betaHepatocyte Nuclear Factor 3-alphaHepatocyte Nuclear Factor 3-betaHepatocyte Nuclear Factor 3-gammaHepatocyte Nuclear Factor 4LiverMolecular Sequence DataNuclear ProteinsOligonucleotidesPhosphoproteinsPrealbuminRatsRNA, MessengerTranscription FactorsTumor Cells, CulturedConceptsTranscription factorsHepatocyte-enriched transcription factorsDNA-binding proteinsTransthyretin gene expressionRegulation of genesDNA-binding activityRat hepatoma cell lineLevel of expressionTranscriptional activityGene expressionHepatoma cell lineDifferential regulationCellular concentrationGenesHepatoma cellsCell linesExpressionRegulationTransthyretin geneLFB1HNF4HNF3ProteinEBPDifferent rates
1990
The mouse albumin enhancer contains a negative regulatory element that interacts with a novel DNA-binding protein.
Herbst RS, Boczko EM, Darnell JE, Babiss LE. The mouse albumin enhancer contains a negative regulatory element that interacts with a novel DNA-binding protein. Molecular And Cellular Biology 1990, 10: 3896-3905. PMID: 2370857, PMCID: PMC360900, DOI: 10.1128/mcb.10.8.3896.Peer-Reviewed Original ResearchConceptsDNA-binding sitesMouse albumin enhancerNovel DNA-binding proteinAlbumin enhancerNegative regulatory domainDNA-binding proteinsNegative regulatory regionDNA-binding activityNegative regulatory elementPositive-acting elementsOrientation-independent fashionRegulatory domainRegulatory regionsAlbumin gene transcriptionGene transcriptionRegulatory elementsEnhancer functionNew proteinsCap siteTissue specificityAlbumin geneCell typesProteinNonhepatic cellsEnhancerThe state of cellular differentiation determines the activity of the adenovirus E1A enhancer element: evidence for negative regulation of enhancer function
Herbst RS, Pelletier M, Boczko EM, Babiss LE. The state of cellular differentiation determines the activity of the adenovirus E1A enhancer element: evidence for negative regulation of enhancer function. Journal Of Virology 1990, 64: 161-172. PMID: 2136708, PMCID: PMC249075, DOI: 10.1128/jvi.64.1.161-172.1990.Peer-Reviewed Original ResearchMeSH KeywordsAdenovirus Early ProteinsAdenoviruses, HumanAnimalsBase SequenceCell DifferentiationCell LineCell NucleusDNA-Binding ProteinsEnhancer Elements, GeneticGene ExpressionGene Expression Regulation, ViralGenes, ViralHeLa CellsHumansMolecular Sequence DataMutationOncogene Proteins, ViralPromoter Regions, GeneticRNA, MessengerSuppression, GeneticTranscription, GeneticViral Structural ProteinsConceptsE1A gene transcriptionFetal fibroblast cellsGene transcriptionHepatoma cell lineFibroblast cellsCell phenotypeCell linesLiver hepatocytesRodent hepatocytesRat liver hepatocytesSimilar binding activityFurther suppressionHeLa cellsEnhancer elementsCellsBinding activityHepatocytesViral genomeDifferentiated cellsE1A enhancerNegative regulationCellular differentiationImportant mechanismPhenotypeHigh levels
1989
Positive and negative regulatory elements in the mouse albumin enhancer.
Herbst RS, Friedman N, Darnell JE, Babiss LE. Positive and negative regulatory elements in the mouse albumin enhancer. Proceedings Of The National Academy Of Sciences Of The United States Of America 1989, 86: 1553-1557. PMID: 2922398, PMCID: PMC286736, DOI: 10.1073/pnas.86.5.1553.Peer-Reviewed Original Research
1987
Factors that interact with the rat albumin promoter are present both in hepatocytes and other cell types.
Babiss LE, Herbst RS, Bennett AL, Darnell JE. Factors that interact with the rat albumin promoter are present both in hepatocytes and other cell types. Genes & Development 1987, 1: 256-267. PMID: 3678823, DOI: 10.1101/gad.1.3.256.Peer-Reviewed Original Research