2024
Motor and sensory impairment in survivors of childhood central nervous system (CNS) tumors in the St. Jude Lifetime Cohort (SJLIFE)
Rodwin R, Wang F, Lu L, Li Z, Srivastava D, Phillips N, Khan R, Brinkman T, Krull K, Boop F, Armstrong G, Merchant T, Gajjar A, Robison L, Hudson M, Kadan‐Lottick N, Ness K. Motor and sensory impairment in survivors of childhood central nervous system (CNS) tumors in the St. Jude Lifetime Cohort (SJLIFE). Cancer Medicine 2024, 13: e7422. PMID: 39056576, PMCID: PMC11273544, DOI: 10.1002/cam4.7422.Peer-Reviewed Original ResearchConceptsSt. Jude Lifetime CohortQuality of lifeChildhood central nervous systemSurvivors of childhood CNS tumorsSensory impairmentChildhood CNS tumorsImpaired physical quality of lifeCentral nervous systemPhysical quality of lifeMotor impairmentCNS tumorsCommon Terminology Criteria for Adverse EventsModified total neuropathy scoreMultivariate modelIn-person evaluationAssociated with older ageClinical assessmentTotal Neuropathy ScoreNervous systemExposure to etoposideModified Common Terminology Criteria for Adverse EventsPrevalence of motorTreating motor impairmentIn-personCraniospinal irradiation
2022
Patient-reported neurocognitive function in adult survivors of childhood and adolescent osteosarcoma and Ewing sarcoma
Kadan-Lottick NS, Zheng DJ, Wang M, Bishop MW, Srivastava DK, Ross WL, Rodwin RL, Ness KK, Gibson TM, Spunt SL, Okcu MF, Leisenring WM, Robison LL, Armstrong GT, Krull KR. Patient-reported neurocognitive function in adult survivors of childhood and adolescent osteosarcoma and Ewing sarcoma. Journal Of Cancer Survivorship 2022, 17: 1238-1250. PMID: 35059962, PMCID: PMC9300774, DOI: 10.1007/s11764-021-01154-z.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBone NeoplasmsCancer SurvivorsHumansNeoplasmsOsteosarcomaSarcoma, EwingSurvivorsConceptsChronic health conditionsLong-term neurocognitive outcomesNeurocognitive outcomesNeurocognitive difficultiesChildhood osteosarcomaHealth conditionsChildhood Cancer Survivor Study Neurocognitive QuestionnaireAdult survivorsModified Poisson regressionPotential risk factorsOsteosarcoma survivorsSarcoma survivorsNeurocognitive QuestionnaireRisk factorsHigh prevalenceEwing's sarcomaPatient reportsNeurological conditionsRespiratory conditionsTreatment exposureNeurocognitive functionPoisson regressionOsteosarcomaDiagnostic groupsComorbid impairments
2021
Newly identified chemotherapy‐induced peripheral neuropathy in a childhood cancer survivorship clinic
Rodwin RL, Ross WL, Rotatori J, Allen K, Auerbach C, Balsamo LM, Kadan‐Lottick N. Newly identified chemotherapy‐induced peripheral neuropathy in a childhood cancer survivorship clinic. Pediatric Blood & Cancer 2021, 69: e29550. PMID: 34971076, PMCID: PMC8805800, DOI: 10.1002/pbc.29550.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAntineoplastic AgentsCancer SurvivorsChildFemaleHumansMaleNeoplasmsPeripheral Nervous System DiseasesSurvivorshipA Case of Pheochromocytoma as a Subsequent Neoplasm in a Survivor of Childhood Embryonal Rhabdomyosarcoma
Rodwin RL, Janardan SK, Hofstatter EW, Kadan-Lottick NS. A Case of Pheochromocytoma as a Subsequent Neoplasm in a Survivor of Childhood Embryonal Rhabdomyosarcoma. Journal Of Pediatric Hematology/Oncology 2021, 44: e585-e588. PMID: 35200227, PMCID: PMC8873988, DOI: 10.1097/mph.0000000000002270.Peer-Reviewed Case Reports and Technical NotesConceptsChildhood embryonal rhabdomyosarcomaSubsequent neoplasmsEmbryonal rhabdomyosarcomaGenetic testingPathogenic variantsCase of pheochromocytomaChildhood cancer survivorsCancer predispositionClinical presentationCancer survivorsGenetic cancer predispositionClinical implicationsUncertain significanceNeoplasmsRhabdomyosarcomaSurvivorsPredispositionPheochromocytomaBladderTestingDeafnessVariantsWomenLongitudinal Evaluation of Neuromuscular Dysfunction in Long-term Survivors of Childhood Cancer: A Report from the Childhood Cancer Survivor Study
Rodwin RL, Chen Y, Yasui Y, Leisenring WM, Gibson TM, Nathan PC, Howell RM, Krull KR, Mohrmann C, Hayashi RJ, Chow EJ, Oeffinger KC, Armstrong GT, Ness KK, Kadan-Lottick NS. Longitudinal Evaluation of Neuromuscular Dysfunction in Long-term Survivors of Childhood Cancer: A Report from the Childhood Cancer Survivor Study. Cancer Epidemiology Biomarkers & Prevention 2021, 30: 1536-1545. PMID: 34099519, PMCID: PMC8523186, DOI: 10.1158/1055-9965.epi-21-0154.Peer-Reviewed Original ResearchConceptsChildhood Cancer Survivor StudyChildhood cancer survivorsCancer Survivor StudyNeuromuscular dysfunctionCumulative incidenceSpinal radiotherapyYears postdiagnosisCancer survivorsPrevalence ratiosSurvivor StudyCentral nervous system tumorsLong-term survivorsNervous system tumorsLater obesityRadiotherapy doseCNS tumorsSystem tumorsChildhood cancerMultivariable modelPlatinum exposureDysfunctionLongitudinal evaluationSurvivorsPrevalenceRadiation exposure