2022
Longitudinal serum proteomics analyses identify unique and overlapping host response pathways in Lyme disease and West Nile virus infection
Boada P, Fatou B, Belperron A, Sigdel T, Smolen K, Wurie Z, Levy O, Ronca S, Murray K, Liberto J, Rashmi P, Kerwin M, Montgomery R, Bockenstedt L, Steen H, Sarwal M. Longitudinal serum proteomics analyses identify unique and overlapping host response pathways in Lyme disease and West Nile virus infection. Frontiers In Immunology 2022, 13: 1012824. PMID: 36569838, PMCID: PMC9784464, DOI: 10.3389/fimmu.2022.1012824.Peer-Reviewed Original ResearchConceptsWest Nile virus infectionLyme diseaseVirus infectionWNV infectionSerum proteomeSymptomatic WNV infectionTime of diagnosisHealthy control seraDisseminated Lyme diseaseHost response pathwaysExtracellular bacterial infectionsSerum proteomic analysisIntracellular viral infectionsViral infectionHost responseBacterial infectionsControl seraStudy participantsInfectionDiseaseDisease biomarkersEarly diagnosticsLC/MSMolecular mechanismsRecovery phase
2014
Reduced bioenergetics and toll-like receptor 1 function in human polymorphonuclear leukocytes in aging
Qian F, Guo X, Wang X, Yuan X, Chen S, Malawista SE, Bockenstedt LK, Allore HG, Montgomery RR. Reduced bioenergetics and toll-like receptor 1 function in human polymorphonuclear leukocytes in aging. Aging 2014, 6: 131-139. PMID: 24595889, PMCID: PMC3969281, DOI: 10.18632/aging.100642.Peer-Reviewed Original ResearchConceptsToll-like receptor 1Polymorphonuclear leukocytesOlder adultsChemokine IL-8Loss of CD62LAge-dependent deficienciesPotential therapeutic opportunitiesHuman polymorphonuclear leukocytesTLR1 expressionIL-8PMN functionPMN activationMultiple pathwaysImmune functionYoung donorsP38 MAP kinaseReceptor 1Bacterial infectionsTherapeutic opportunitiesProgressive declineGlucose uptakeReduced expressionAdultsStimulationLeukocytes
2013
Functional Polymorphisms in the Gene Encoding Macrophage Migration Inhibitory Factor Are Associated With Gram-Negative Bacteremia in Older Adults
Das R, Subrahmanyan L, Yang IV, van Duin D, Levy R, Piecychna M, Leng L, Montgomery RR, Shaw A, Schwartz DA, Bucala R. Functional Polymorphisms in the Gene Encoding Macrophage Migration Inhibitory Factor Are Associated With Gram-Negative Bacteremia in Older Adults. The Journal Of Infectious Diseases 2013, 209: 764-768. PMID: 24158957, PMCID: PMC3923543, DOI: 10.1093/infdis/jit571.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorMigration inhibitory factorLow expressionOlder adultsInhibitory factorSurface Toll-like receptor 4Toll-like receptor 4Gram-negative bacteremiaPeripheral blood monocytesNegative bacterial infectionsMIF productionImmune mediatorsNegative bacteremiaHealthy controlsReceptor 4Blood monocytesOlder subjectsBacterial infectionsFunctional polymorphismsHigh expressionBacteremiaAdultsExpressionPatientsCohort