2017
Aging impairs both primary and secondary RIG-I signaling for interferon induction in human monocytes
Molony RD, Nguyen JT, Kong Y, Montgomery RR, Shaw AC, Iwasaki A. Aging impairs both primary and secondary RIG-I signaling for interferon induction in human monocytes. Science Signaling 2017, 10 PMID: 29233916, PMCID: PMC6429941, DOI: 10.1126/scisignal.aan2392.Peer-Reviewed Original ResearchConceptsType I IFNsI IFNsI interferonOlder adultsIFN inductionRetinoic acid-inducible gene IAcid-inducible gene IHealthy human donorsType I interferonRespiratory influenzaProinflammatory cytokinesVirus infectionType I IFN genesAdult monocytesAntiviral resistanceTranscription factor IRF8IFN responseHuman donorsMonocytesIncreased proteasomal degradationHuman monocytesYoung adultsIRF8 expressionIAV RNAInfected cells
2012
Quantitative imaging of lineage-specific Toll-like receptor-mediated signaling in monocytes and dendritic cells from small samples of human blood.
Qian F, Montgomery RR. Quantitative imaging of lineage-specific Toll-like receptor-mediated signaling in monocytes and dendritic cells from small samples of human blood. Journal Of Visualized Experiments 2012 PMID: 22525943, PMCID: PMC3466655, DOI: 10.3791/3741.Peer-Reviewed Original ResearchConceptsToll-like receptorsDendritic cellsImmune responseToll-like receptor-mediated signalingCell-mediated immune responsesCertain Toll-like receptorsAntigen-presenting cellsPeripheral blood monocytesHealthy human donorsNF-κB pathwayInnate immune systemReceptor-mediated signalingQuantitative flow cytometryTLR levelsWest Nile virusPatient susceptibilityUnderstanding of immunosenescenceImmune responsivenessElderly donorsLarge cohortOlder donorsAdaptive immunityBlood monocytesNF-κBTherapeutic interventions