2017
Aging impairs both primary and secondary RIG-I signaling for interferon induction in human monocytes
Molony RD, Nguyen JT, Kong Y, Montgomery RR, Shaw AC, Iwasaki A. Aging impairs both primary and secondary RIG-I signaling for interferon induction in human monocytes. Science Signaling 2017, 10 PMID: 29233916, PMCID: PMC6429941, DOI: 10.1126/scisignal.aan2392.Peer-Reviewed Original ResearchConceptsType I IFNsI IFNsI interferonOlder adultsIFN inductionRetinoic acid-inducible gene IAcid-inducible gene IHealthy human donorsType I interferonRespiratory influenzaProinflammatory cytokinesVirus infectionType I IFN genesAdult monocytesAntiviral resistanceTranscription factor IRF8IFN responseHuman donorsMonocytesIncreased proteasomal degradationHuman monocytesYoung adultsIRF8 expressionIAV RNAInfected cells
1993
The fate of Borrelia burgdorferi, the agent for Lyme disease, in mouse macrophages. Destruction, survival, recovery.
Montgomery RR, Nathanson MH, Malawista SE. The fate of Borrelia burgdorferi, the agent for Lyme disease, in mouse macrophages. Destruction, survival, recovery. The Journal Of Immunology 1993, 150: 909-15. PMID: 8423346, DOI: 10.4049/jimmunol.150.3.909.Peer-Reviewed Original ResearchConceptsUptake of spirochetesConfocal fluorescence microscopyLikely candidate siteEndocytic pathwayB. burgdorferiBorrelia burgdorferiFluorescence microscopyIntracellular persistenceLyme diseaseInfected cellsPersistence of spirochetesMouse macrophagesIntracellular organismsPositive compartmentsPossible pathogenetic mechanismsExtracellular organismsOrganismsAcridine orangeCellsMultiple time pointsPathogenetic mechanismsSpirochetesInfectious agentsCompartmentsLyme spirochete