1993
The fate of Borrelia burgdorferi, the agent for Lyme disease, in mouse macrophages. Destruction, survival, recovery.
Montgomery RR, Nathanson MH, Malawista SE. The fate of Borrelia burgdorferi, the agent for Lyme disease, in mouse macrophages. Destruction, survival, recovery. The Journal Of Immunology 1993, 150: 909-15. PMID: 8423346, DOI: 10.4049/jimmunol.150.3.909.Peer-Reviewed Original ResearchConceptsUptake of spirochetesConfocal fluorescence microscopyLikely candidate siteEndocytic pathwayB. burgdorferiBorrelia burgdorferiFluorescence microscopyIntracellular persistenceLyme diseaseInfected cellsPersistence of spirochetesMouse macrophagesIntracellular organismsPositive compartmentsPossible pathogenetic mechanismsExtracellular organismsOrganismsAcridine orangeCellsMultiple time pointsPathogenetic mechanismsSpirochetesInfectious agentsCompartmentsLyme spirochete
1991
Accumulation of indigestible substances reduces fusion competence of macrophage lysosomes.
Montgomery RR, Webster P, Mellman I. Accumulation of indigestible substances reduces fusion competence of macrophage lysosomes. The Journal Of Immunology 1991, 147: 3087-95. PMID: 1919007, DOI: 10.4049/jimmunol.147.9.3087.Peer-Reviewed Original Research
1986
Effects of reagent and cell-generated hydrogen peroxide on the properties of low density lipoprotein.
Montgomery RR, Nathan CF, Cohn ZA. Effects of reagent and cell-generated hydrogen peroxide on the properties of low density lipoprotein. Proceedings Of The National Academy Of Sciences Of The United States Of America 1986, 83: 6631-6635. PMID: 3018740, PMCID: PMC386558, DOI: 10.1073/pnas.83.17.6631.Peer-Reviewed Original ResearchConceptsLow-density lipoproteinDensity lipoproteinHuman monocytesModification of LDLUntreated low-density lipoproteinOxidation of LDLThiobarbituric acidAortic endothelial cell linePhorbol myristate acetateEndothelial cell lineReactive oxygen intermediatesCell line monolayersRespiratory burstMyristate acetateMacrophagesMouse macrophagesReagent H2O2Cell linesOxygen intermediatesMonocytesLipoproteinTBA reactivityHuman plasmaMaximal oxidation