2001
Murine Lyme Disease: No Evidence for Active Immune Down-Regulation in Resolving or Subclinical Infection
Montgomery R, Wang X, Malawista S. Murine Lyme Disease: No Evidence for Active Immune Down-Regulation in Resolving or Subclinical Infection. The Journal Of Infectious Diseases 2001, 183: 1631-1637. PMID: 11343212, DOI: 10.1086/320703.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBorrelia burgdorferi GroupDisease Models, AnimalFemaleFluorescent Antibody TechniqueInterleukin-1Interleukin-12Lyme DiseaseMacrophage ActivationMacrophagesMiceMyocarditisPeritoneumReverse Transcriptase Polymerase Chain ReactionRNA, MessengerSpecific Pathogen-Free OrganismsTumor Necrosis Factor-alphaConceptsActive diseaseAnti-inflammatory cytokine IL-10Proinflammatory cytokines IL-1Levels of proinflammatoryAnti-inflammatory cytokinesCytokine IL-10Double-label immunofluorescent stainingCytokines IL-1Reverse transcription-polymerase chain reaction analysisSemiquantitative reverse transcription-polymerase chain reaction (RT-PCR) analysisTranscription-polymerase chain reaction analysisInfected heartsIL-10IL-12Inflammatory activityCytokine expressionTumor necrosisLocal macrophagesIL-1Peritoneal cavitySubclinical infectionChain reaction analysisLevels of mRNAMacrophage activationImmune system
2000
Functional Competence of Peritoneal Macrophages in Murine Lyme Borreliosis
Montgomery R, Palmarozza R, Beck D, Ngo E, Joiner K, Malawista S. Functional Competence of Peritoneal Macrophages in Murine Lyme Borreliosis. Inflammation 2000, 24: 277-288. DOI: 10.1023/a:1007017630980.Peer-Reviewed Original ResearchPeritoneal macrophagesB-cell activation markersCell activation markersMurine Lyme borreliosisProportion of lymphocytesSensitive functional measuresAcridine orange vital stainingState of activationActivation markersInfected miceLavage fluidConfocal microscopyChronic diseasesT cellsImmune clearanceSuch micePeritoneal cavityPhagocyte functionUninfected controlsMacrophage functionB cellsToxoplasma gondiiInfected animalsLyme borreliosisFunctional measures