2022
Analytical Approaches to Uncover Genetic Associations for Rare Outcomes: Lessons from West Nile Neuroinvasive Disease
Cahill M, Montgomery R. Analytical Approaches to Uncover Genetic Associations for Rare Outcomes: Lessons from West Nile Neuroinvasive Disease. Methods In Molecular Biology 2022, 2585: 193-203. PMID: 36331775, PMCID: PMC9867870, DOI: 10.1007/978-1-0716-2760-0_17.Peer-Reviewed Original ResearchConceptsWest Nile neuroinvasive diseaseNeuroinvasive diseaseViral infectionWest Nile viral infectionSevere neuroinvasive diseaseMore severe outcomesGenetic factorsRare outcomesLimited cohort sizeSevere West Nile neuroinvasive diseaseWest Nile infectionVector-borne viral infectionSevere outcomesImmune responseSevere diseaseHigh riskFatal diseaseVaccine developmentInfectionDiseaseInfected humansWest NileSerious diseaseOutcomesCohort size
2020
In-Depth Analysis of Genetic Variation Associated with Severe West Nile Viral Disease
Cahill ME, Loeb M, Dewan AT, Montgomery RR. In-Depth Analysis of Genetic Variation Associated with Severe West Nile Viral Disease. Vaccines 2020, 8: 744. PMID: 33302579, PMCID: PMC7768385, DOI: 10.3390/vaccines8040744.Peer-Reviewed Original ResearchAdditional novel variantsWest Nile virusNovel genetic variantsComprehensive genetic studiesGenetic Variation AssociatedGenetic architectureGene-gene interaction analysisNovel lociGene targetsLocus analysisBiological roleGenetic studiesGenetic variantsVirus datasetCell linesVariation AssociatedSevere West Nile neuroinvasive diseaseNovel variantsMosquito-borne virusViable targetViral diseasesNile virusInteraction analysisGenesLoci