Featured Publications
Loss of ATRX confers DNA repair defects and PARP inhibitor sensitivity
Garbarino J, Eckroate J, Sundaram RK, Jensen RB, Bindra RS. Loss of ATRX confers DNA repair defects and PARP inhibitor sensitivity. Translational Oncology 2021, 14: 101147. PMID: 34118569, PMCID: PMC8203843, DOI: 10.1016/j.tranon.2021.101147.Peer-Reviewed Original ResearchPARP inhibitor sensitivityInhibitor sensitivityKey DNA damage response pathwaysDNA damage response pathwayFunction of ATRXHR-defective cellsDamage response pathwayAlpha thalassemia/mental retardation syndrome XDNA repair defectsLoss of ATRXHistone chaperonesHistone variantsReplication stressMental retardation syndrome XModel cell lineResponse pathwaysEpistatic interactionsDNA repairGene targetingAtaxia telangiectasiaKO cellsIsocitrate dehydrogenase 1DDR defectsMolecular markersRepair defects
2001
ATM-dependent expression of the insulin-like growth factor-I receptor in a pathway regulating radiation response
Peretz S, Jensen R, Baserga R, Glazer P. ATM-dependent expression of the insulin-like growth factor-I receptor in a pathway regulating radiation response. Proceedings Of The National Academy Of Sciences Of The United States Of America 2001, 98: 1676-1681. PMID: 11172010, PMCID: PMC29316, DOI: 10.1073/pnas.98.4.1676.Peer-Reviewed Original ResearchConceptsWild-type cellsIGF-IR promoter activityAT cellsAtaxia telangiectasiaPromoter activityLevel of transcriptionHeterologous viral promotersDominant negative fragmentTyrosine kinase activityCell surface receptorsATM cDNAIGF-IR expressionIGF-IRInhibition of apoptosisATM functionAT syndromeKinase activityViral promotersCDNA resultsCell transformationInsulin-like growthATM geneSurface receptorsGrowth abnormalitiesExtreme radiosensitivity