Polymerase θ Coordinates Multiple Intrinsic Enzymatic Activities during DNA Repair
Zahn KE, Jensen RB. Polymerase θ Coordinates Multiple Intrinsic Enzymatic Activities during DNA Repair. Genes 2021, 12: 1310. PMID: 34573292, PMCID: PMC8470613, DOI: 10.3390/genes12091310.Peer-Reviewed Original ResearchConceptsPolymerase θAmino acid protein productDNA double-strand break repair pathwayDouble-strand break repair pathwayTemplate-dependent DNA polymerasesDNA-dependent ATPaseDNA double-strand breaksBreak repair pathwayIntrinsic enzymatic activitySynthetic lethal strategyDouble-strand breaksDrug target candidatesDNA repair defectsDNA polymerase θSmall molecule inhibitorsPARP inhibitor resistanceHomologous recombinationDNA repairLyase functionRepair pathwaysEnzymatic functionProtein productsLethal strategiesRepair defectsBRCA-mutant cancersLoss of ATRX confers DNA repair defects and PARP inhibitor sensitivity
Garbarino J, Eckroate J, Sundaram RK, Jensen RB, Bindra RS. Loss of ATRX confers DNA repair defects and PARP inhibitor sensitivity. Translational Oncology 2021, 14: 101147. PMID: 34118569, PMCID: PMC8203843, DOI: 10.1016/j.tranon.2021.101147.Peer-Reviewed Original ResearchPARP inhibitor sensitivityInhibitor sensitivityKey DNA damage response pathwaysDNA damage response pathwayFunction of ATRXHR-defective cellsDamage response pathwayAlpha thalassemia/mental retardation syndrome XDNA repair defectsLoss of ATRXHistone chaperonesHistone variantsReplication stressMental retardation syndrome XModel cell lineResponse pathwaysEpistatic interactionsDNA repairGene targetingAtaxia telangiectasiaKO cellsIsocitrate dehydrogenase 1DDR defectsMolecular markersRepair defects