2017
Structural and functional analyses of the mammalian TIN2-TPP1-TRF2 telomeric complex
Hu C, Rai R, Huang C, Broton C, Long J, Xu Y, Xue J, Lei M, Chang S, Chen Y. Structural and functional analyses of the mammalian TIN2-TPP1-TRF2 telomeric complex. Cell Research 2017, 27: 1485-1502. PMID: 29160297, PMCID: PMC5717407, DOI: 10.1038/cr.2017.144.Peer-Reviewed Original ResearchConceptsShelterin complexTelomeric DNAStructure-based mutagenesis analysisProtein-protein interaction platformRepetitive DNA sequencesTelomere end protectionN-terminal domainMammalian telomeresChromosome endsTelomeric complexNucleoprotein complexesMutagenesis analysisEnd protectionDNA sequencesLike domainHeterodimer bindsTIN2Functional analysisMolecular mechanismsTRF2TPP1Stable assemblyEssential roleTRF1Telomeres
2009
Gcn5 and SAGA Regulate Shelterin Protein Turnover and Telomere Maintenance
Atanassov BS, Evrard YA, Multani AS, Zhang Z, Tora L, Devys D, Chang S, Dent SY. Gcn5 and SAGA Regulate Shelterin Protein Turnover and Telomere Maintenance. Molecular Cell 2009, 35: 352-364. PMID: 19683498, PMCID: PMC2749492, DOI: 10.1016/j.molcel.2009.06.015.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCells, CulturedChromosome AberrationsDNA Breaks, Double-StrandedDNA RepairGene DeletionHumansMiceModels, BiologicalP300-CBP Transcription FactorsProteasome InhibitorsProtein StabilityShelterin ComplexTelomereTelomere-Binding ProteinsTelomeric Repeat Binding Protein 1Thiolester HydrolasesUbiquitin ThiolesteraseConceptsSAGA complexTelomeric shelterin complexDeletion of GCN5Accessibility of chromatinBona fide componentTRF1 levelsGene regulationShelterin complexTelomere maintenanceMammalian cellsTranscription factorsGCN5DNA repairFide componentRepair proteinsTelomere dysfunctionProtein turnoverHuman cellsUbiquitin-specific protease 22Biochemical studiesOverexpression of USP22USP22ComplexesTurnoverChromatin
2008
Telomere dysfunction and tumour suppression: the senescence connection
Deng Y, Chan SS, Chang S. Telomere dysfunction and tumour suppression: the senescence connection. Nature Reviews Cancer 2008, 8: 450-458. PMID: 18500246, PMCID: PMC3688269, DOI: 10.1038/nrc2393.Peer-Reviewed Original ResearchConceptsTelomere dysfunctionDysfunctional telomeresDNA damage responseKey PointsTelomeresEukaryotic chromosomesGenome instabilityShelterin complexApoptotic programDamage responseRepetitive sequencesCellular senescenceTelomeric endTumor suppressionProtein resultsP53 pathwayMutant p53TelomeresSpontaneous tumorigenesisSenescenceTumorigenesisMouse modelChromosomesDysfunctionProteinApoptosisInitiation of Genomic Instability, Cellular Senescence, and Organismal Aging by Dysfunctional Telomeres
Chang S. Initiation of Genomic Instability, Cellular Senescence, and Organismal Aging by Dysfunctional Telomeres. 2008, 57-75. DOI: 10.1007/978-3-540-73709-4_4.Peer-Reviewed Original ResearchDysfunctional telomeresOrganismal agingCellular senescenceDNA damage responseLinear chromosomesShelterin complexDamage responseTelomeric repeatsGenomic instabilityTelomeric structureTelomeresSenescenceFunction resultsProteinImportant roleChromosomesMouse modelRepeatsTelomeraseDNAProgressive lossP53ActivationComplexesAging