ABC triblock bottlebrush copolymer-based injectable hydrogels: design, synthesis, and application to expanding the therapeutic index of cancer immunochemotherapy
Vohidov F, Milling L, Chen Q, Zhang W, Bhagchandani S, Nguyen H, Irvine D, Johnson J. ABC triblock bottlebrush copolymer-based injectable hydrogels: design, synthesis, and application to expanding the therapeutic index of cancer immunochemotherapy. Chemical Science 2020, 11: 5974-5986. PMID: 34094088, PMCID: PMC8159417, DOI: 10.1039/d0sc02611e.Peer-Reviewed Original ResearchRing-opening metathesis polymerizationBottlebrush copolymersDrug deliveryCritical solution temperatureSustained drug releasePolyethylene glycolPolylactic acidActive small moleculesMetathesis polymerizationMacromolecular architecturesTBC micellesAqueous mediaPolymer networksDrug releaseVersatile scaffoldHydrogel formationPNIPAM domainsPLA domainsVersatile classSolution temperatureMicellar solutionsPhysical crosslinksSmall moleculesFirst exampleHydrogels