2018
Towards an arthritis flare-responsive drug delivery system
Joshi N, Yan J, Levy S, Bhagchandani S, Slaughter K, Sherman N, Amirault J, Wang Y, Riegel L, He X, Rui T, Valic M, Vemula P, Miranda O, Levy O, Gravallese E, Aliprantis A, Ermann J, Karp J. Towards an arthritis flare-responsive drug delivery system. Nature Communications 2018, 9: 1275. PMID: 29615615, PMCID: PMC5882944, DOI: 10.1038/s41467-018-03691-1.Peer-Reviewed Original ResearchConceptsTriamcinolone acetonideInflammatory arthritisArthritis activityFree triamcinolone acetonideIA therapyArthritic miceRheumatoid arthritisArthritis flaresLocal drug delivery methodSingle doseDrug delivery methodsSynovial fluidDrug delivery approachEquivalent doseLocal deliveryArthritisDoseDelivery approachDrug delivery systemsTreatmentDelivery methodsDelivery systemPatientsTherapyIA severity
2016
A prodrug-doped cellular Trojan Horse for the potential treatment of prostate cancer
Levy O, Brennen W, Han E, Rosen D, Musabeyezu J, Safaee H, Ranganath S, Ngai J, Heinelt M, Milton Y, Wang H, Bhagchandani S, Joshi N, Bhowmick N, Denmeade S, Isaacs J, Karp J. A prodrug-doped cellular Trojan Horse for the potential treatment of prostate cancer. Biomaterials 2016, 91: 140-150. PMID: 27019026, PMCID: PMC4824400, DOI: 10.1016/j.biomaterials.2016.03.023.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntineoplastic AgentsCell Line, TumorCells, CulturedDrug Delivery SystemsHumansLactic AcidMaleMesenchymal Stem Cell TransplantationMesenchymal Stem CellsMice, NudePolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerProdrugsProstateProstate-Specific AntigenProstatic NeoplasmsConceptsMesenchymal stem cellsDelivery platformDrug delivery platformSystemic delivery platformHuman mesenchymal stem cellsCell-based deliveryGenetic engineeringProstate cancerDisseminated prostate cancerPCa cell linesProstate-specific antigenProstate cancer researchLoaded cellsMicroparticlesStem cellsPromising approachPCa xenograftsMetastatic PCaPlatformCancer sitesAnti-cancer drugsPotential treatmentSpecific antigenCancer growthTumor growth