2021
Evolution of Toll-like receptor 7/8 agonist therapeutics and their delivery approaches: From antiviral formulations to vaccine adjuvants
Bhagchandani S, Johnson J, Irvine D. Evolution of Toll-like receptor 7/8 agonist therapeutics and their delivery approaches: From antiviral formulations to vaccine adjuvants. Advanced Drug Delivery Reviews 2021, 175: 113803. PMID: 34058283, PMCID: PMC9003539, DOI: 10.1016/j.addr.2021.05.013.Peer-Reviewed Original ResearchMeSH KeywordsAdjuvants, VaccineAnimalsAntineoplastic AgentsAntiviral AgentsDrug Delivery SystemsHumansImmunomodulating AgentsToll-Like Receptor 7Toll-Like Receptor 8ConceptsVaccine adjuvantsImidazoquinoline derivativesToll-like receptor 7Candidate vaccine adjuvantsSkin cancer treatmentBroad therapeutic utilityTLR7 toleranceTopical antiviralsImmunomodulatory agentsReceptor 7Systemic administrationPoor pharmacokinetic propertiesTherapeutic utilitySuccessful clinical translationSynthetic agonistsAntiviral formulationsInfectious diseasesPharmacokinetic propertiesCancer treatmentBroad expression profileAdjuvantClinical translationBiodistributionExpression profilesTherapeutics
2016
A prodrug-doped cellular Trojan Horse for the potential treatment of prostate cancer
Levy O, Brennen W, Han E, Rosen D, Musabeyezu J, Safaee H, Ranganath S, Ngai J, Heinelt M, Milton Y, Wang H, Bhagchandani S, Joshi N, Bhowmick N, Denmeade S, Isaacs J, Karp J. A prodrug-doped cellular Trojan Horse for the potential treatment of prostate cancer. Biomaterials 2016, 91: 140-150. PMID: 27019026, PMCID: PMC4824400, DOI: 10.1016/j.biomaterials.2016.03.023.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntineoplastic AgentsCell Line, TumorCells, CulturedDrug Delivery SystemsHumansLactic AcidMaleMesenchymal Stem Cell TransplantationMesenchymal Stem CellsMice, NudePolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerProdrugsProstateProstate-Specific AntigenProstatic NeoplasmsConceptsMesenchymal stem cellsDelivery platformDrug delivery platformSystemic delivery platformHuman mesenchymal stem cellsCell-based deliveryGenetic engineeringProstate cancerDisseminated prostate cancerPCa cell linesProstate-specific antigenProstate cancer researchLoaded cellsMicroparticlesStem cellsPromising approachPCa xenograftsMetastatic PCaPlatformCancer sitesAnti-cancer drugsPotential treatmentSpecific antigenCancer growthTumor growth