2021
Type of bony involvement predicts genomic subgroup in sphenoid wing meningiomas
Jin L, Youngblood MW, Gupte TP, Vetsa S, Nadar A, Barak T, Yalcin K, Aguilera SM, Mishra-Gorur K, Blondin NA, Gorelick E, Omay SB, Pointdujour-Lim R, Judson BL, Alperovich M, Aboian MS, McGuone D, Gunel M, Erson-Omay Z, Fulbright RK, Moliterno J. Type of bony involvement predicts genomic subgroup in sphenoid wing meningiomas. Journal Of Neuro-Oncology 2021, 154: 237-246. PMID: 34350560, DOI: 10.1007/s11060-021-03819-2.Peer-Reviewed Original ResearchConceptsSpheno-orbital meningiomasSphenoid wing meningiomaBony involvementTRAF7 mutationsGenomic subgroupsPre-operative clinical featuresTumor invasionYale-New Haven HospitalAdditional clinical variablesSubset of tumorsPre-operative predictionWhole-exome sequencingBone involvementBone invasionClinical featuresClinical variablesGrade IIMolecular subtypesRecurrence patternsClinical implicationsHyperostosisExome sequencingMeningiomasTumorsGenomic drivers
2017
Limitations of the endonasal endoscopic approach in treating olfactory groove meningiomas. A systematic review
Shetty SR, Ruiz-Treviño AS, Omay SB, Almeida JP, Liang B, Chen YN, Singh H, Schwartz TH. Limitations of the endonasal endoscopic approach in treating olfactory groove meningiomas. A systematic review. Acta Neurochirurgica 2017, 159: 1875-1885. PMID: 28831590, DOI: 10.1007/s00701-017-3303-0.Peer-Reviewed Original ResearchConceptsExtent of resectionOlfactory groove meningiomasTCA groupEndoscopic endonasalEEA patientsEEA groupTraditional transcranialPreoperative visual disturbancesMedium-sized tumorsFischer's exact testEndonasal endoscopic approachT-testStudent's t-testCurrent management strategiesPostoperative anosmiaPreoperative anosmiaTCA patientsPostoperative complicationsVisual outcomeEndoscopic resectionVisual disturbancesRecurrence rateSkull base reconstructionEndoscopic approachCSF leakPredictors and incidence of orthostatic headache associated with lumbar drain placement following endoscopic endonasal skull base surgery
Liang B, Shetty SR, Omay SB, Almeida JP, Ni S, Chen YN, Ruiz-Treviño AS, Anand VK, Schwartz TH. Predictors and incidence of orthostatic headache associated with lumbar drain placement following endoscopic endonasal skull base surgery. Acta Neurochirurgica 2017, 159: 1379-1385. PMID: 28643170, DOI: 10.1007/s00701-017-3247-4.Peer-Reviewed Original ResearchConceptsEndoscopic endonasal skull base surgeryEndoscopic endonasal proceduresIntracranial hypotensionEndonasal skull base surgeryBlood patchSkull base surgeryEndonasal proceduresEpidural blood patchResultsTwo hundred fortyYoung female patientLumbar drain placementOH patientsInfrequent complicationPatient demographicsFemale patientsConsecutive seriesDrain durationOrthostatic headacheDrain placementLumbar drainagePotential complicationsRisk factorsFemale genderHundred fortyRadiographic signsEndonasal endoscopic pituitary surgery in the elderly.
Wilson PJ, Omay SB, Kacker A, Anand VK, Schwartz TH. Endonasal endoscopic pituitary surgery in the elderly. Journal Of Neurosurgery 2017, 128: 429-436. PMID: 28387628, DOI: 10.3171/2016.11.jns162286.Peer-Reviewed Original ResearchMeSH KeywordsAdenomaAgedAged, 80 and overBlood Loss, SurgicalDatabases, FactualFemaleHumansLength of StayMaleMiddle AgedNasal CavityNatural Orifice Endoscopic SurgeryNeurosurgical ProceduresPituitary GlandPituitary NeoplasmsPostoperative ComplicationsRetrospective StudiesSphenoid BoneTreatment OutcomeConceptsComplication rateEndonasal endoscopic surgeryElderly patientsPituitary adenomasEndoscopic surgeryEndoscopic endonasal transsphenoidal resectionAge groupsEndonasal transsphenoidal resectionSymptomatic subdural hygromasIntraoperative blood lossRisk of complicationsRisk of surgeryExtent of resectionSingle-center dataAverage tumor diameterHealthy young personsLength of stayEndonasal endoscopic pituitary surgeryEndonasal endoscopic approachEndoscopic pituitary surgeryCranial complicationsPostoperative hematomaSymptomatic patientsBlood lossRetrospective reviewLongitudinal analysis of treatment-induced genomic alterations in gliomas
Erson-Omay EZ, Henegariu O, Omay SB, Harmancı AS, Youngblood MW, Mishra-Gorur K, Li J, Özduman K, Carrión-Grant G, Clark VE, Çağlar C, Bakırcıoğlu M, Pamir MN, Tabar V, Vortmeyer AO, Bilguvar K, Yasuno K, DeAngelis LM, Baehring JM, Moliterno J, Günel M. Longitudinal analysis of treatment-induced genomic alterations in gliomas. Genome Medicine 2017, 9: 12. PMID: 28153049, PMCID: PMC5290635, DOI: 10.1186/s13073-017-0401-9.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic AgentsChromosome AberrationsCombined Modality TherapyDisease ProgressionDNA Mismatch RepairDNA Mutational AnalysisDNA, NeoplasmExomeFemaleGeneral SurgeryGenome, HumanGenomicsGlioblastomaHumansImmunotherapyLongitudinal StudiesMiddle AgedMutationNeoplasm Recurrence, LocalPrecision MedicineRadiotherapyTreatment OutcomeConceptsWhole-exome sequencingMismatch repair deficiencyImmune checkpoint inhibitionMalignant brain tumorsMolecular changesLongitudinal analysisMedian survivalCheckpoint inhibitionSubsequent recurrenceMaximal resectionStandard treatmentBackgroundGlioblastoma multiformeBrain tumorsTumor-normal pairsFavorable responsePrimary GBMIndividual tumorsConclusionsOur studyPrecision therapyPersonalized treatmentGenomic profilingRepair deficiencyGenomic alterationsGenomic profilesTherapy
2015
Lung Cancer Brain Metastases
Goldberg SB, Contessa JN, Omay SB, Chiang V. Lung Cancer Brain Metastases. The Cancer Journal 2015, 21: 398-403. PMID: 26389765, DOI: 10.1097/ppo.0000000000000146.Peer-Reviewed Original ResearchConceptsLung cancer brain metastasesCancer brain metastasesBrain metastasesCentral nervous systemLung cancerSystemic therapyNervous systemIntracranial disease burdenOverall cancer prognosisSystemic therapy optionsExtracranial diseaseSelect patientsLocal therapySignificant morbidityTumor histologyIntracranial metastasesTherapy optionsDisease burdenSurgical techniqueAppropriate treatmentDurable benefitEffective treatmentCancer prognosisPatientsMetastasis
2014
Gamma Knife Radiosurgery for Cerebellopontine Angle Meningiomas: A Multicenter Study
Ding D, Starke RM, Kano H, Nakaji P, Barnett GH, Mathieu D, Chiang V, Omay SB, Hess J, McBride HL, Honea N, Lee JY, Rahmathulla G, Evanoff WA, Alonso-Basanta M, Lunsford LD, Sheehan JP. Gamma Knife Radiosurgery for Cerebellopontine Angle Meningiomas: A Multicenter Study. Neurosurgery 2014, 75: 398-408. PMID: 24991710, DOI: 10.1227/neu.0000000000000480.Peer-Reviewed Original ResearchConceptsGamma knife radiosurgeryCerebellopontine angle meningiomaNeurological deteriorationCPA meningiomasKnife radiosurgeryNorth American Gamma Knife ConsortiumSymptomatic adverse radiation effectsTumor progressionLower maximal dosePermanent neurological deteriorationCommon presenting symptomInitial surgical resectionMulticenter cohort studyOutcomes of patientsProgression-free survivalSignificant neurological morbidityMedian tumor volumeAdverse radiation effectsMultivariate regression analysisAdjuvant treatmentNeurological morbidityPresenting symptomCohort studyMost patientsSurgical resection
2013
Maxillary swing approach for extended infratemporal fossa tumors
Otremba M, Adam S, Omay SB, Lowlicht R, Bulsara KR, Judson B. Maxillary swing approach for extended infratemporal fossa tumors. The Laryngoscope 2013, 123: 1607-1611. PMID: 23536535, DOI: 10.1002/lary.23947.Peer-Reviewed Original Research
2012
Decompressive hemicraniectomy for ischemic stroke in the pediatric population
Omay SB, Carrión-Grant GM, Kuzmik GA, Fu M, Grant R, Schindler JL, Diluna ML, Duncan CC, Bulsara KR. Decompressive hemicraniectomy for ischemic stroke in the pediatric population. Neurosurgical Review 2012, 36: 21-25. PMID: 22886322, DOI: 10.1007/s10143-012-0411-4.Peer-Reviewed Original ResearchConceptsDecompressive hemicraniectomyPediatric populationAdult patientsSpace-occupying hemispheric infarctionMaximal medical therapyMalignant strokeHemispheric infarctionIschemic strokeSymptom onsetMedical therapyPediatric patientsPoor prognosisTreatment optionsPediatric literatureFatality ratePatientsAdult populationPediatric interventionsPositive outcomesOptimal timingHemicraniectomyReasonable outcomesOutcomesStrokeCurrent literature