2021
Comprehensive Genomic Characterization of A Case of Granular Cell Tumor of the Posterior Pituitary Gland: A Case Report
Hong CS, Elsamadicy AA, Fisayo A, Inzucchi SE, Gopal PP, Vining EM, Erson-Omay EZ, Omay S. Comprehensive Genomic Characterization of A Case of Granular Cell Tumor of the Posterior Pituitary Gland: A Case Report. Frontiers In Endocrinology 2021, 12: 762095. PMID: 34925233, PMCID: PMC8671743, DOI: 10.3389/fendo.2021.762095.Peer-Reviewed Original ResearchConceptsGranular cell tumorPosterior pituitary glandCell tumorsPituitary glandComprehensive genomic characterizationWhole-exome sequencingImmune checkpoint inhibitorsPoor clinical outcomePituitary gland tumorsHistone deacetylase inhibitorsInstitutional review boardRadiographic compressionUnderwent resectionCheckpoint inhibitorsMedical therapyPituitary massClinical outcomesOptic nerveSignificant morbidityResidual diseaseCase reportCentral hypothyroidismPharmacologic agentsGland tumorsTherapeutic targetingPIK3CA mutation in a case of CTNNB1 mutant sinonasal glomangiopericytoma
Hong C, Khan M, Sukys J, Prasad M, Erson-Omay EZ, Vining E, Omay SB. PIK3CA mutation in a case of CTNNB1 mutant sinonasal glomangiopericytoma. Molecular Case Studies 2021, 8: mcs.a006120. PMID: 34667073, PMCID: PMC8744496, DOI: 10.1101/mcs.a006120.Peer-Reviewed Original ResearchConceptsCase of glomangiopericytomaWhole-exome sequencingInstitutional review board-approved protocolTargeted medical therapyUnderwent surgical resectionPI3K/Akt/mTORWnt/β-cateninAkt/mTORPrimary sinonasal tumorSurgical resectionClinicopathologic characteristicsMedical therapyRare tumorPIK3CA mutationsSinonasal tumorsGlomangiopericytomaTumorsΒ-cateninSomatic mutationsComprehensive genetic characterizationGenomic characterizationMutationsConcurrent dysregulationResectionSinonasal
2020
Association of race and ethnicity to incident epilepsy, or epileptogenesis, after subdural hematoma.
Brown SC, King ZA, Kuohn L, Kamel H, Gilmore EJ, Frontera JA, Murthy S, Kim JA, Omay SB, Falcone GJ, Sheth KN. Association of race and ethnicity to incident epilepsy, or epileptogenesis, after subdural hematoma. Neurology 2020, 95: e2890-e2899. PMID: 32907969, PMCID: PMC7734738, DOI: 10.1212/wnl.0000000000010742.Peer-Reviewed Original ResearchConceptsSubdural hematomaEmergency departmentMultivariable Cox regressionRetrospective cohort studyMedical risk factorsDevelopment of epilepsyNontraumatic subdural hematomaAssociation of raceDiagnosis of epilepsyCohort studyPrimary outcomeRenal diseaseStatus epilepticusWhite patientsBlack patientsHospital revisitsCox regressionBlack raceDiagnosis codesRisk factorsClaims dataInjury severityEpilepsyDrug useSurvival analysisPembrolizumab for management of patients with NSCLC and brain metastases: long-term results and biomarker analysis from a non-randomised, open-label, phase 2 trial
Goldberg SB, Schalper KA, Gettinger SN, Mahajan A, Herbst RS, Chiang AC, Lilenbaum R, Wilson FH, Omay SB, Yu JB, Jilaveanu L, Tran T, Pavlik K, Rowen E, Gerrish H, Komlo A, Gupta R, Wyatt H, Ribeiro M, Kluger Y, Zhou G, Wei W, Chiang VL, Kluger HM. Pembrolizumab for management of patients with NSCLC and brain metastases: long-term results and biomarker analysis from a non-randomised, open-label, phase 2 trial. The Lancet Oncology 2020, 21: 655-663. PMID: 32251621, PMCID: PMC7380514, DOI: 10.1016/s1470-2045(20)30111-x.Peer-Reviewed Original ResearchConceptsBrain metastasis responseYale Cancer CenterPD-L1 expressionPhase 2 trialUntreated brain metastasesBrain metastasesAdrenal insufficiencyAdverse eventsMetastasis responseCNS diseaseCancer CenterCohort 2Cohort 1Eastern Cooperative Oncology Group performance statusTreatment-related serious adverse eventsModified Response Evaluation CriteriaStage IV NSCLCTreatment-related deathsAcute kidney injuryPD-1 blockadeSerious adverse eventsSolid Tumors criteriaPhase 2 studyProportion of patientsResponse Evaluation Criteria
2017
Is the chiasm-pituitary corridor size important for achieving gross-total resection during endonasal endoscopic resection of craniopharyngiomas?
Omay SB, Almeida JP, Chen YN, Shetty SR, Liang B, Ni S, Anand VK, Schwartz TH. Is the chiasm-pituitary corridor size important for achieving gross-total resection during endonasal endoscopic resection of craniopharyngiomas? Journal Of Neurosurgery 2017, 129: 642-647. PMID: 29171802, DOI: 10.3171/2017.6.jns163188.Peer-Reviewed Original ResearchConceptsGross total resectionExtended endonasal approachSubtotal resectionLarge tumorsPituitary glandFirst-line surgical approachEndonasal endoscopic resectionAvailable preoperative imagingMidline craniopharyngiomasOBJECTIVE CraniopharyngiomasPrefixed chiasmEndocrine outcomesRelative contraindicationVisual outcomeEndoscopic resectionAuthors' centerPreoperative imagingOptic chiasmSurgical approachVisual deteriorationResults ThirtyPituitary stalkThird ventricleHigh riskResectionTransorbital endoscopic eyelid approach for resection of sphenoorbital meningiomas with predominant hyperostosis: report of 2 cases.
Almeida JP, Omay SB, Shetty SR, Chen YN, Ruiz-Treviño AS, Liang B, Anand VK, Levine B, Schwartz TH. Transorbital endoscopic eyelid approach for resection of sphenoorbital meningiomas with predominant hyperostosis: report of 2 cases. Journal Of Neurosurgery 2017, 128: 1885-1895. PMID: 28862553, DOI: 10.3171/2017.3.jns163110.Peer-Reviewed Original ResearchConceptsSphenoorbital meningiomasEyelid approachIntraconal tumorsEndoscopic approachIntracranial componentOcular movement disordersOptic nerve compressionGross total resectionStandard of careTransorbital endoscopic approachAdjacent hyperostosisEndonasal decompressionPrior craniotomyRadiographic outcomesNerve compressionHigh morbiditySphenoidal wingPostoperative measurementsVisual deteriorationOrbital apexPlaque diseaseIntracranial portionInvasive alternativeMovement disordersSurgical techniqueDo craniopharyngioma molecular signatures correlate with clinical characteristics?
Omay SB, Chen YN, Almeida JP, Ruiz-Treviño AS, Boockvar JA, Stieg PE, Greenfield JP, Souweidane MM, Kacker A, Pisapia DJ, Anand VK, Schwartz TH. Do craniopharyngioma molecular signatures correlate with clinical characteristics? Journal Of Neurosurgery 2017, 128: 1473-1478. PMID: 28707994, DOI: 10.3171/2017.1.jns162232.Peer-Reviewed Original ResearchConceptsPapillary craniopharyngiomasAdamantinomatous craniopharyngiomaMutation groupPostoperative clinical symptomsSubgroup of tumorsMolecular signaturesWeill Cornell Medical CollegeND tumorsClinical characteristicsCornell Medical CollegeClinical symptomsClinical variablesGroup tumorsRadiographic featuresResults HistologyBRAF mutationsCraniopharyngiomaAge groupsMedical CollegeTumorsExome sequencing studiesCTNNB1 mutationsOutcome variablesHistologyPatientsTranstubular excisional biopsy as a rescue for a non-diagnostic stereotactic needle biopsy—case report and literature review
Chen YN, Omay SB, Shetty SR, Liang B, Almeida JP, Ruiz-Treviño AS, Lavi E, Schwartz TH. Transtubular excisional biopsy as a rescue for a non-diagnostic stereotactic needle biopsy—case report and literature review. Acta Neurochirurgica 2017, 159: 1589-1595. PMID: 28688051, DOI: 10.1007/s00701-017-3260-7.Peer-Reviewed Original ResearchPredictors and incidence of orthostatic headache associated with lumbar drain placement following endoscopic endonasal skull base surgery
Liang B, Shetty SR, Omay SB, Almeida JP, Ni S, Chen YN, Ruiz-Treviño AS, Anand VK, Schwartz TH. Predictors and incidence of orthostatic headache associated with lumbar drain placement following endoscopic endonasal skull base surgery. Acta Neurochirurgica 2017, 159: 1379-1385. PMID: 28643170, DOI: 10.1007/s00701-017-3247-4.Peer-Reviewed Original ResearchConceptsEndoscopic endonasal skull base surgeryEndoscopic endonasal proceduresIntracranial hypotensionEndonasal skull base surgeryBlood patchSkull base surgeryEndonasal proceduresEpidural blood patchResultsTwo hundred fortyYoung female patientLumbar drain placementOH patientsInfrequent complicationPatient demographicsFemale patientsConsecutive seriesDrain durationOrthostatic headacheDrain placementLumbar drainagePotential complicationsRisk factorsFemale genderHundred fortyRadiographic signsEndonasal endoscopic pituitary surgery in the elderly.
Wilson PJ, Omay SB, Kacker A, Anand VK, Schwartz TH. Endonasal endoscopic pituitary surgery in the elderly. Journal Of Neurosurgery 2017, 128: 429-436. PMID: 28387628, DOI: 10.3171/2016.11.jns162286.Peer-Reviewed Original ResearchMeSH KeywordsAdenomaAgedAged, 80 and overBlood Loss, SurgicalDatabases, FactualFemaleHumansLength of StayMaleMiddle AgedNasal CavityNatural Orifice Endoscopic SurgeryNeurosurgical ProceduresPituitary GlandPituitary NeoplasmsPostoperative ComplicationsRetrospective StudiesSphenoid BoneTreatment OutcomeConceptsComplication rateEndonasal endoscopic surgeryElderly patientsPituitary adenomasEndoscopic surgeryEndoscopic endonasal transsphenoidal resectionAge groupsEndonasal transsphenoidal resectionSymptomatic subdural hygromasIntraoperative blood lossRisk of complicationsRisk of surgeryExtent of resectionSingle-center dataAverage tumor diameterHealthy young personsLength of stayEndonasal endoscopic pituitary surgeryEndonasal endoscopic approachEndoscopic pituitary surgeryCranial complicationsPostoperative hematomaSymptomatic patientsBlood lossRetrospective review
2014
Gamma Knife Radiosurgery for Cerebellopontine Angle Meningiomas: A Multicenter Study
Ding D, Starke RM, Kano H, Nakaji P, Barnett GH, Mathieu D, Chiang V, Omay SB, Hess J, McBride HL, Honea N, Lee JY, Rahmathulla G, Evanoff WA, Alonso-Basanta M, Lunsford LD, Sheehan JP. Gamma Knife Radiosurgery for Cerebellopontine Angle Meningiomas: A Multicenter Study. Neurosurgery 2014, 75: 398-408. PMID: 24991710, DOI: 10.1227/neu.0000000000000480.Peer-Reviewed Original ResearchConceptsGamma knife radiosurgeryCerebellopontine angle meningiomaNeurological deteriorationCPA meningiomasKnife radiosurgeryNorth American Gamma Knife ConsortiumSymptomatic adverse radiation effectsTumor progressionLower maximal dosePermanent neurological deteriorationCommon presenting symptomInitial surgical resectionMulticenter cohort studyOutcomes of patientsProgression-free survivalSignificant neurological morbidityMedian tumor volumeAdverse radiation effectsMultivariate regression analysisAdjuvant treatmentNeurological morbidityPresenting symptomCohort studyMost patientsSurgical resection
2013
Genomic Analysis of Non-NF2 Meningiomas Reveals Mutations in TRAF7, KLF4, AKT1, and SMO
Clark VE, Erson-Omay EZ, Serin A, Yin J, Cotney J, Özduman K, Avşar T, Li J, Murray PB, Henegariu O, Yilmaz S, Günel JM, Carrión-Grant G, Yılmaz B, Grady C, Tanrıkulu B, Bakırcıoğlu M, Kaymakçalan H, Caglayan AO, Sencar L, Ceyhun E, Atik AF, Bayri Y, Bai H, Kolb LE, Hebert RM, Omay SB, Mishra-Gorur K, Choi M, Overton JD, Holland EC, Mane S, State MW, Bilgüvar K, Baehring JM, Gutin PH, Piepmeier JM, Vortmeyer A, Brennan CW, Pamir MN, Kılıç T, Lifton RP, Noonan JP, Yasuno K, Günel M. Genomic Analysis of Non-NF2 Meningiomas Reveals Mutations in TRAF7, KLF4, AKT1, and SMO. Science 2013, 339: 1077-1080. PMID: 23348505, PMCID: PMC4808587, DOI: 10.1126/science.1233009.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBrain NeoplasmsChromosomes, Human, Pair 22DNA Mutational AnalysisFemaleGenes, Neurofibromatosis 2Genomic InstabilityGenomicsHumansKruppel-Like Factor 4Kruppel-Like Transcription FactorsMaleMeningeal NeoplasmsMeningiomaMiddle AgedMutationNeoplasm GradingProto-Oncogene Proteins c-aktReceptors, G-Protein-CoupledSmoothened ReceptorTumor Necrosis Factor Receptor-Associated Peptides and Proteins
2011
Primary Central Nervous System Vasculitis Presenting as Spinal Subdural Hematoma
Fu M, Omay SB, Morgan J, Kelley B, Abbed K, Bulsara KR. Primary Central Nervous System Vasculitis Presenting as Spinal Subdural Hematoma. World Neurosurgery 2011, 78: 192.e5-192.e8. PMID: 22120304, DOI: 10.1016/j.wneu.2011.07.043.Peer-Reviewed Original ResearchConceptsPrimary central nervous system vasculitisSpinal subdural hematomaCentral nervous systemSpinal cord vasculitisSubdural hematomaNervous systemAcute spinal subdural hematomaCentral nervous system vasculitisPrimary central nervous systemAcute hypertensive eventSystemic inflammatory disorderVascular inflammatory conditionsMagnetic resonance imagingEmergent laminectomyHypertensive eventsCerebral edemaVasculitic processIntracranial vasculitisInflammatory disordersTypical presentationInflammatory conditionsSpinal cordUnreported etiologyDifferential diagnosisVasculitis
2009
Unusual presentations of nervous system infection by Cryptococcus neoformans
Searls D, Sico JJ, Omay S, Bannykh S, Kuohung V, Baehring J. Unusual presentations of nervous system infection by Cryptococcus neoformans. Clinical Neurology And Neurosurgery 2009, 111: 638-642. PMID: 19541406, DOI: 10.1016/j.clineuro.2009.05.007.Peer-Reviewed Original ResearchConceptsNervous system infectionHuman immunodeficiency virusSystem infectionCryptococcal meningitisNeurological manifestationsCryptococcus neoformansRecurrent cerebral infarctionSevere neurological disabilityC. neoformans infectionUnusual clinical presentationUnusual neurological manifestationsDetailed clinical descriptionMagnetic resonance imagingOphthalmic zosterCryptococcal infectionCerebral infarctionImmunocompetent patientsNeoformans infectionNeurological disabilityClinical presentationHodgkin's diseaseImmunodeficiency syndromeImmunocompetent hostsImmunodeficiency virusCSF analysis