Naltrexone, an opioid receptor antagonist, attenuates liver fibrosis in bile duct ligated rats
Ebrahimkhani MR, Kiani S, Oakley F, Kendall T, Shariftabrizi A, Tavangar SM, Moezi L, Payabvash S, Karoon A, Hoseininik H, Mann DA, Moore KP, Mani AR, Dehpour AR. Naltrexone, an opioid receptor antagonist, attenuates liver fibrosis in bile duct ligated rats. Gut 2006, 55: 1606. PMID: 16543289, PMCID: PMC1860108, DOI: 10.1136/gut.2005.076778.Peer-Reviewed Original ResearchConceptsHepatic stellate cellsProcollagen I expressionHepatic fibrosisBile ductSelective delta-opioid receptor agonistI expressionDelta-opioid receptor agonistAlpha-smooth muscle actinCultured hepatic stellate cellsOpioid receptor antagonistHepatic hydroxyproline levelsEffects of naltrexoneOpioid receptor agonistsHepatic GSH/GSSG ratioReverse transcriptase-polymerase chain reactionTIMP-1 expressionRat hepatic stellate cellsMMP-2 activityTranscriptase-polymerase chain reactionSmooth muscle actinMatrix metalloproteinase-2GSH/GSSG ratioDelta1 receptorsActivated Rat Hepatic Stellate CellsBiliary cirrhosisOpioid system blockade decreases collagenase activity and improves liver injury in a rat model of cholestasis
Kiani S, Ebrahimkhani MR, Shariftabrizi A, Doratotaj B, Payabvash S, Riazi K, Dehghani M, Honar H, Karoon A, Amanlou M, Tavangar SM, Dehpour AR. Opioid system blockade decreases collagenase activity and improves liver injury in a rat model of cholestasis. Journal Of Gastroenterology And Hepatology 2006, 22: 406-413. PMID: 17295775, DOI: 10.1111/j.1440-1746.2006.04260.x.Peer-Reviewed Original ResearchConceptsOpioid receptor blockadeLiver injuryMMP-2 activityNaltrexone treatmentReceptor blockadeCholestasis-induced liver injuryPlasma nitrite/nitrateNitrite/nitrate levelsMatrix metalloproteinase-2 activitySAH ratioManifestation of cholestasisOpioid agonist administrationSham-operated ratsMetalloproteinase-2 activityLiver enzyme activitiesNitrite/nitrateLiver SAM levelsPlasma enzyme activitiesSAM levelsAgonist administrationBDL animalsCholestatic animalsEndogenous opioidsBDL ratsS-adenosylhomocysteine content