2024
Diffusion‐Weighted Imaging Fluid‐Attenuated Inversion Recovery Mismatch on Portable, Low‐Field Magnetic Resonance Imaging Among Acute Stroke Patients
Sorby‐Adams A, Guo J, de Havenon A, Payabvash S, Sze G, Pinter N, Jaikumar V, Siddiqui A, Baldassano S, Garcia‐Guarniz A, Zabinska J, Lalwani D, Peasley E, Goldstein J, Nelson O, Schaefer P, Wira C, Pitts J, Lee V, Muir K, Nimjee S, Kirsch J, Iglesias J, Rosen M, Sheth K, Kimberly W. Diffusion‐Weighted Imaging Fluid‐Attenuated Inversion Recovery Mismatch on Portable, Low‐Field Magnetic Resonance Imaging Among Acute Stroke Patients. Annals Of Neurology 2024, 96: 321-331. PMID: 38738750, PMCID: PMC11293843, DOI: 10.1002/ana.26954.Peer-Reviewed Original ResearchStroke patientsAcute ischemic strokeCut-pointsIschemic strokeStroke patients <Diagnosis of acute ischemic strokeSignal intensity ratioFluid-attenuated inversion recoveryAcute stroke patientsOptimal cut-pointMagnetic resonance imagingDiffusion-weighted imagingDWI-FLAIR mismatchStroke onsetTrained assessorsNational InstituteStrokeThrombolytic interventionNegative predictive valueFLAIR hyperintensitiesPatientsInterobserver agreementHyperacute strokeDiffusion-weightedPredictive valueRadiomics-Based Prediction of Collateral Status from CT Angiography of Patients Following a Large Vessel Occlusion Stroke
Avery E, Abou-Karam A, Abi-Fadel S, Behland J, Mak A, Haider S, Zeevi T, Sanelli P, Filippi C, Malhotra A, Matouk C, Falcone G, Petersen N, Sansing L, Sheth K, Payabvash S. Radiomics-Based Prediction of Collateral Status from CT Angiography of Patients Following a Large Vessel Occlusion Stroke. Diagnostics 2024, 14: 485. PMID: 38472957, PMCID: PMC10930945, DOI: 10.3390/diagnostics14050485.Peer-Reviewed Original ResearchCollateral statusCollateral scoreLarge vessel occlusionAcute LVO strokeRadiomics modelTest cohortCT angiography of patientsAdmission computed tomography angiographyAnterior circulation territoryAngiography of patientsLong-term outcomesReceiver operating characteristic areaRadiomics-based predictionCollateral arterial circulationOperating characteristics areaAdmission CTACirculation territoryCT angiographyClinical outcomesRadiomic featuresTreatment triageOcclusion strokeVessel occlusionPatientsArterial circulationUncertainty-aware deep-learning model for prediction of supratentorial hematoma expansion from admission non-contrast head computed tomography scan
Tran A, Zeevi T, Haider S, Abou Karam G, Berson E, Tharmaseelan H, Qureshi A, Sanelli P, Werring D, Malhotra A, Petersen N, de Havenon A, Falcone G, Sheth K, Payabvash S. Uncertainty-aware deep-learning model for prediction of supratentorial hematoma expansion from admission non-contrast head computed tomography scan. Npj Digital Medicine 2024, 7: 26. PMID: 38321131, PMCID: PMC10847454, DOI: 10.1038/s41746-024-01007-w.Peer-Reviewed Original ResearchDeep learning modelsHematoma expansionIntracerebral hemorrhageICH expansionComputed tomographyNon-contrast head CTNon-contrast head computed tomographyHigh risk of HEHead computed tomographyHigh-confidence predictionsRisk of HENon-contrast headReceiver operating characteristic areaModifiable risk factorsMonte Carlo dropoutOperating characteristics areaPotential treatment targetHead CTVisual markersIdentified patientsAutomated deep learning modelDataset of patientsRisk factorsHigh riskPatients
2023
Trends in Use of Intravenous Thrombolysis and Endovascular Thrombectomy in Patients With Acute Stroke With Large Vessel Occlusion 2016 to 2020 and Impact of COVID‐19 Pandemic
Khunte M, Chen H, Khunte A, Payabvash S, Gandhi D, Malhotra A. Trends in Use of Intravenous Thrombolysis and Endovascular Thrombectomy in Patients With Acute Stroke With Large Vessel Occlusion 2016 to 2020 and Impact of COVID‐19 Pandemic. Journal Of The American Heart Association 2023, 12: e029579. PMID: 37889182, PMCID: PMC10727381, DOI: 10.1161/jaha.122.029579.Peer-Reviewed Original ResearchUtility of Gadolinium-Based Contrast in Initial Evaluation of Seizures in Children Presenting Emergently
Andrijauskis D, Woolf G, Kuehne A, Al-Dasuqi K, Silva C, Payabvash S, Malhotra A. Utility of Gadolinium-Based Contrast in Initial Evaluation of Seizures in Children Presenting Emergently. American Journal Of Neuroradiology 2023, 44: 1208-1211. PMID: 37652579, PMCID: PMC10549952, DOI: 10.3174/ajnr.a7976.Peer-Reviewed Original ResearchConceptsSeizure presentationMR imagingConsecutive pediatric patientsNew-onset seizuresEvaluation of seizuresIschemic/hypoxicImaging of patientsBrain MR imagingGadolinium-based contrast agentsNoncontrast studyAcute onsetHippocampal sclerosisPediatric seizuresPatient agePediatric patientsNormal findingsIntracranial hemorrhageEmergency departmentVascular anomaliesInpatient unitGadolinium contrastPatientsNeurodevelopmental lesionAdditive benefitSeizuresIdentification of White Matter Hyperintensities in Routine Emergency Department Visits Using Portable Bedside Magnetic Resonance Imaging
de Havenon A, Parasuram N, Crawford A, Mazurek M, Chavva I, Yadlapalli V, Iglesias J, Rosen M, Falcone G, Payabvash S, Sze G, Sharma R, Schiff S, Safdar B, Wira C, Kimberly W, Sheth K. Identification of White Matter Hyperintensities in Routine Emergency Department Visits Using Portable Bedside Magnetic Resonance Imaging. Journal Of The American Heart Association 2023, 12: e029242. PMID: 37218590, PMCID: PMC10381997, DOI: 10.1161/jaha.122.029242.Peer-Reviewed Original ResearchConceptsWhite matter hyperintensitiesMagnetic resonance imagingSevere white matter hyperintensitiesConventional magnetic resonance imagingResonance imagingRetrospective cohortEmergency departmentMatter hyperintensitiesVascular risk factorsProspective observational studyVascular cognitive impairmentTesla magnetic resonance imagingArea Deprivation IndexProspective cohortAdult patientsAcute careRisk factorsCardiovascular diseaseObservational studyCognitive impairmentPatientsCare magnetic resonance imagingIntermodality agreementCohortDeprivation index
2022
PET/CT radiomics potentially improves progression-free survival (PFS) and overall survival (OS) prognostication beyond UICC TNM staging in oropharyngeal squamous cell carcinoma (OPSCC) patients
Haider S, Sharaf K, Zeevi T, Mahajan A, Forghani R, Judson B, Kann B, Burtness B, Reichel C, Baumeister P, Payabvash S. PET/CT radiomics potentially improves progression-free survival (PFS) and overall survival (OS) prognostication beyond UICC TNM staging in oropharyngeal squamous cell carcinoma (OPSCC) patients. Laryngo-Rhino-Otologie 2022, 101: s184-s184. DOI: 10.1055/s-0042-1746471.Peer-Reviewed Original ResearchBedside monitoring of hypoxic ischemic brain injury using low-field, portable brain magnetic resonance imaging after cardiac arrest
Beekman R, Crawford A, Mazurek MH, Prabhat AM, Chavva IR, Parasuram N, Kim N, Kim JA, Petersen N, de Havenon A, Khosla A, Honiden S, Miller PE, Wira C, Daley J, Payabvash S, Greer DM, Gilmore EJ, Kimberly W, Sheth KN. Bedside monitoring of hypoxic ischemic brain injury using low-field, portable brain magnetic resonance imaging after cardiac arrest. Resuscitation 2022, 176: 150-158. PMID: 35562094, PMCID: PMC9746653, DOI: 10.1016/j.resuscitation.2022.05.002.Peer-Reviewed Original ResearchConceptsCardiac arrestBrain injuryHypoxic-ischemic brain injuryAdverse neurological outcomesIschemic brain injurySingle-center studyBrain magnetic resonanceBrain injury severityBoard-certified neuroradiologistsLow-field MRIFLAIR signal intensityNeurological outcomeCA patientsIll patientsMRI findingsCA survivorsCenter studyMRI examinationsClinical careHigh riskInjury severityPatientsSignal intensityBedside monitoringMR imagingCost-effectiveness of thrombectomy in patients with minor stroke and large vessel occlusion: effect of thrombus location on cost-effectiveness and outcomes
Khunte M, Wu X, Koo A, Payabvash S, Matouk C, Heit JJ, Wintermark M, Albers GW, Sanelli PC, Gandhi D, Malhotra A. Cost-effectiveness of thrombectomy in patients with minor stroke and large vessel occlusion: effect of thrombus location on cost-effectiveness and outcomes. Journal Of NeuroInterventional Surgery 2022, 15: 39-45. PMID: 35022300, DOI: 10.1136/neurintsurg-2021-018375.Peer-Reviewed Original ResearchConceptsLarge vessel occlusionProximal M1 occlusionEndovascular thrombectomyMinor strokeM2 occlusionsIntravenous thrombolysisM1 occlusionMedical managementVessel occlusionRankin score 0Markov decision-analytic modelBase-case analysisDecision analytic modelProbabilistic sensitivity analysesProximal M1More patientsPoor outcomeThrombus locationDistal M1Occlusion siteObservational studyScore 0Significant disabilityBetter outcomesPatientsBedside detection of intracranial midline shift using portable magnetic resonance imaging
Sheth KN, Yuen MM, Mazurek MH, Cahn BA, Prabhat AM, Salehi S, Shah JT, By S, Welch EB, Sofka M, Sacolick LI, Kim JA, Payabvash S, Falcone GJ, Gilmore EJ, Hwang DY, Matouk C, Gordon-Kundu B, RN AW, Petersen N, Schindler J, Gobeske KT, Sansing LH, Sze G, Rosen MS, Kimberly WT, Kundu P. Bedside detection of intracranial midline shift using portable magnetic resonance imaging. Scientific Reports 2022, 12: 67. PMID: 34996970, PMCID: PMC8742125, DOI: 10.1038/s41598-021-03892-7.Peer-Reviewed Original ResearchConceptsMidline shiftNeuroscience intensive care unitCare measurementYale-New Haven HospitalValuable bedside toolIntensive care unitPoor clinical outcomeBrain-injured patientsMass effectNew Haven HospitalMagnetic resonance imagingClinical outcomesIll patientsCare unitStroke patientsFunctional outcomeBedside toolObservational studyBedside detectionImaging examsPatientsResonance imagingPortable MRIImaging suiteSignificant concordance
2021
Early head CT in post-cardiac arrest patients: A helpful tool or contributor to self-fulfilling prophecy?
Beekman R, Maciel CB, Ormseth CH, Zhou SE, Galluzzo D, Miyares LC, Torres-Lopez VM, Payabvash S, Mak A, Greer DM, Gilmore EJ. Early head CT in post-cardiac arrest patients: A helpful tool or contributor to self-fulfilling prophecy? Resuscitation 2021, 165: 68-76. PMID: 34147572, DOI: 10.1016/j.resuscitation.2021.06.004.Peer-Reviewed Original ResearchConceptsGray-white matter ratioHCT findingsArrest patientsInter-rater reliabilityPost-cardiac arrest patientsTertiary care academic medical centerEarly head CTPost-CA carePost-CA patientsCardiac arrest patientsHalf of casesAcademic medical centerElectronic medical recordsWithdrawal of lifeNeurophysiologic testingSpontaneous circulationInjury burdenMedical recordsHead CTTherapeutic decisionsMedical CenterPatientsNeurointensivistsHctTemperature managementCost-effectiveness of endovascular thrombectomy in patients with low Alberta Stroke Program Early CT Scores (< 6) at presentation.
Wu X, Payabvash S, Matouk CC, Lev MH, Wintermark M, Sanelli P, Gandhi D, Malhotra A. Cost-effectiveness of endovascular thrombectomy in patients with low Alberta Stroke Program Early CT Scores (< 6) at presentation. Journal Of Neurosurgery 2021, 135: 1645-1655. PMID: 33962378, DOI: 10.3171/2020.9.jns202965.Peer-Reviewed Original ResearchAlberta Stroke Program Early CT ScoreLow Alberta Stroke Program Early CT ScoreEndovascular thrombectomyLarge vessel occlusionMedical managementCT scoreBetter outcomesCost-effective strategyEVT-treated patientsIncremental cost-effectiveness ratioAcute ischemic strokeCost-effectiveness ratioDecision-analytical studyIschemic strokePoor outcomeVessel occlusionLifetime horizonSignificant disabilityPatientsHealth outcomesAge groupsPerfect healthSocietal perspectiveQALYHealth benefitsImaging of Spontaneous Intracerebral Hemorrhage
Jain A, Malhotra A, Payabvash S. Imaging of Spontaneous Intracerebral Hemorrhage. Neuroimaging Clinics Of North America 2021, 31: 193-203. PMID: 33902874, PMCID: PMC8820948, DOI: 10.1016/j.nic.2021.02.003.Peer-Reviewed Original ResearchConceptsIntracerebral hemorrhageSpontaneous intracerebral hemorrhageStroke incidenceLatest evidence-based guidelinesNontraumatic spontaneous intracerebral hemorrhageHemorrhagic stroke incidenceOverall stroke incidenceIdentification of patientsEvidence-based guidelinesClinical outcome predictionMorbidity rateHematoma expansionTreatment strategiesFirst monthOutcome predictionHemorrhageMortalityIncidenceFirst yearPatientsStrokeNeuroimagingMonths
2020
Outcomes after Thrombectomy for Minor Stroke: A Meta-Analysis
Wu X, Khunte M, Payabvash S, Zhu C, Brackett A, Matouk CC, Gandhi D, Sanelli P, Malhotra A. Outcomes after Thrombectomy for Minor Stroke: A Meta-Analysis. World Neurosurgery 2020, 149: e1140-e1154. PMID: 33359881, DOI: 10.1016/j.wneu.2020.12.047.Peer-Reviewed Original ResearchConceptsSymptomatic intracranial hemorrhageBest medical managementMedical managementMechanical thrombectomyExcellent outcomesBetter outcomesImmediate thrombectomyMinor strokeIncidence of sICHLarge vessel occlusionSignificant selection biasStroke symptomatologyIntravenous thrombolysisBaseline characteristicsPooled proportionIntracranial hemorrhageOdds ratioThrombectomyMT outcomesMeta-AnalysisPatientsMortalityOutcomesStrokeSelection biasCost-effectiveness of endovascular thrombectomy in patients with acute stroke and M2 occlusion
Khunte M, Wu X, Payabvash S, Zhu C, Matouk C, Schindler J, Sanelli P, Gandhi D, Malhotra A. Cost-effectiveness of endovascular thrombectomy in patients with acute stroke and M2 occlusion. Journal Of NeuroInterventional Surgery 2020, 13: 784-789. PMID: 33077578, DOI: 10.1136/neurintsurg-2020-016765.Peer-Reviewed Original ResearchConceptsEndovascular thrombectomyMedical managementProbabilistic sensitivity analysesM2 occlusionsAcute strokeBranch occlusionEVT-treated patientsAcute ischemic strokeQuality-adjusted life yearsLifetime quality-adjusted life yearsDecision analytic modelDecision analytic studyIschemic strokeReperfusion techniquesLifetime horizonBetter outcomesPatientsLife yearsAge groupsPerfect healthSocietal perspectiveCost-effective strategyStrokeHealth benefitsOcclusionChoice of imaging modality for pre-treatment staging of head and neck cancer impacts TNM staging
Mur T, Sambhu KM, Mahajan A, Payabvash S, Fernandez J, Edwards HA. Choice of imaging modality for pre-treatment staging of head and neck cancer impacts TNM staging. American Journal Of Otolaryngology 2020, 41: 102662. PMID: 32858370, DOI: 10.1016/j.amjoto.2020.102662.Peer-Reviewed Original ResearchConceptsPET/CTLow-dose nonenhanced CTDistant metastasisChest CTNeck cancerNonenhanced CTF-fluorodeoxyglucose positron emission tomographyF-FDG PET/CTDiagnostic chest CTDistant metastatic diseaseInitiation of therapyRetrospective cohort studyPre-treatment stagingTertiary care settingSignificant differencesPositron emission tomographyMetastatic diseaseCohort studyOncologic treatmentTNM stagingInaccurate stagingNeck radiologistsCare settingsSingle patientPatients
2019
Multi-Institutional Validation of Deep Learning for Pretreatment Identification of Extranodal Extension in Head and Neck Squamous Cell Carcinoma.
Kann BH, Hicks DF, Payabvash S, Mahajan A, Du J, Gupta V, Park HS, Yu JB, Yarbrough WG, Burtness BA, Husain ZA, Aneja S. Multi-Institutional Validation of Deep Learning for Pretreatment Identification of Extranodal Extension in Head and Neck Squamous Cell Carcinoma. Journal Of Clinical Oncology 2019, 38: 1304-1311. PMID: 31815574, DOI: 10.1200/jco.19.02031.Peer-Reviewed Original ResearchConceptsNeck squamous cell carcinomaExtranodal extensionSquamous cell carcinomaLymph nodesCell carcinomaContrast-enhanced CT scanDiagnostic abilityBoard-certified neuroradiologistsTreatment escalationCancer Genome AtlasPathologic confirmationPretreatment identificationDiagnostic challengeExternal validation data setsPathology resultsPretreatment imagingPoor prognosticatorClinical utilityCT scanPatientsClinical decisionHNSCCDiagnostic accuracyInstitutional ValidationGenome AtlasStroke atlas of the brain: Voxel-wise density-based clustering of infarct lesions topographic distribution
Wang Y, Juliano JM, Liew SL, McKinney AM, Payabvash S. Stroke atlas of the brain: Voxel-wise density-based clustering of infarct lesions topographic distribution. NeuroImage Clinical 2019, 24: 101981. PMID: 31473544, PMCID: PMC6728875, DOI: 10.1016/j.nicl.2019.101981.Peer-Reviewed Original ResearchConceptsMain cerebral arteriesInfarct lesionsSupply territoryCerebral arteryBrain tissueLarge arterial occlusionDeep white matterGray matter nucleiStandard brain spaceIschemic infarctArterial occlusionConsensus atlasMRI scansWhite matterLesionsTopographic distributionPatientsClusters of voxelsBrainArteryBrain spaceMother clustersMothersTiny clustersVisual assessment
2018
Quantitative diffusion magnetic resonance imaging in head and neck tumors
Payabvash S. Quantitative diffusion magnetic resonance imaging in head and neck tumors. Quantitative Imaging In Medicine And Surgery 2018, 8: 1052-1065. PMID: 30598882, PMCID: PMC6288053, DOI: 10.21037/qims.2018.10.14.Peer-Reviewed Original ResearchNeck tumorsMagnetic resonance imaging (MRI) scansPrimary malignant processMetastatic lymph nodesResonance imaging scansQuantitative diffusion magnetic resonanceAnatomical magnetic resonance imaging scanLymph nodesPrimary lesionNeck cancerImaging scansTreatment responseMalignant processTumor pathologyPosttreatment changesDiffusion magnetic resonanceDiffusion MRIPrognostic predictionAnatomical evaluationPrimary malignant tissueQuantitative diffusion MRITreatment monitoringMalignant tissuesPatientsTumors
2016
Prominent cortical and medullary veins on susceptibility-weighted images of acute ischaemic stroke
Payabvash S, Benson JC, Taleb S, Rykken JB, Hoffman B, Oswood MC, McKinney AM. Prominent cortical and medullary veins on susceptibility-weighted images of acute ischaemic stroke. British Journal Of Radiology 2016, 89: 20160714. PMID: 27805839, PMCID: PMC5604931, DOI: 10.1259/bjr.20160714.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeLarger infarct volumesMedullary veinsIschemic strokeInfarct volumeArterial occlusionSusceptibility-weighted imagesConsecutive patientsClinical outcomesCortical veinsProminent cortical veinsPosterior circulation territoryPoor clinical outcomeSeverity of symptomsFair interobserver agreementSWI seriesAcute strokeSymptom onsetIndependent predictorsClinical variablesSWI scansPatientsStrokeImaging implicationsProminent veins