2007
Salutary Effects of N-Acetylcysteine on Apoptotic Damage in a Rat Model of Testicular Torsion
Payabvash S, Salmasi AH, Kiumehr S, Tavangar SM, Nourbakhsh B, Faghihi SH, Dehpour AR. Salutary Effects of N-Acetylcysteine on Apoptotic Damage in a Rat Model of Testicular Torsion. Urologia Internationalis 2007, 79: 248-254. PMID: 17940358, DOI: 10.1159/000107958.Peer-Reviewed Original ResearchConceptsAdministration of NACGerm cell apoptosis indicesIschemia/reperfusion injuryTorsion/detorsionCell apoptosis indexRat modelN-acetylcysteineApoptosis indexReperfusion injuryTesticular torsionProtective effectGroup 2Control groupTesticular torsion/detorsionNAC 30 minRenal tissue damageSprague-Dawley ratsGroup 1 animalsGerm cell apoptosisIntraperitoneal injectionSham operationSaline injectionSystemic administrationTherapeutic doseAntioxidant balance
2006
Nitric oxide modulates glutathione synthesis during endotoxemia
Payabvash S, Ghahremani MH, Goliaei A, Mandegary A, Shafaroodi H, Amanlou M, Dehpour AR. Nitric oxide modulates glutathione synthesis during endotoxemia. Free Radical Biology And Medicine 2006, 41: 1817-1828. PMID: 17157184, DOI: 10.1016/j.freeradbiomed.2006.09.010.Peer-Reviewed Original ResearchConceptsNitric oxide synthesisOxide synthesisHepatic glutathione synthesisGlutathione levelsGlutathione synthesisInjection of lipopolysaccharideHepatic glutathione concentrationHepatic glutathione levelsEndotoxin-induced changesNitric oxide formationIntracellular glutathione levelsEndotoxemic miceLiver glutathioneEndotoxemiaNitric oxideGlutathione peroxidaseGlutathione fluxOxidative stressGlutathione concentrationGlutathione statusAntioxidant defenseGlutathione S-transferaseCysteine precursorLipopolysaccharideGlutathione metabolism
2005
Paradoxical dose- and time-dependent regulation of superoxide dismutase and antioxidant capacity by vitamin E in rat
Golestani A, Rastegar R, Shariftabrizi A, Khaghani S, Payabvash SM, Salmasi AH, Dehpour AR, Pasalar P. Paradoxical dose- and time-dependent regulation of superoxide dismutase and antioxidant capacity by vitamin E in rat. Clinica Chimica Acta 2005, 365: 153-159. PMID: 16183047, DOI: 10.1016/j.cca.2005.08.008.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntioxidantsDose-Response Relationship, DrugMaleRatsRats, Sprague-DawleySuperoxide DismutaseVitamin EConceptsDosing groupVitamin ESOD activityAntioxidant capacitySignificant decreaseErythrocyte SOD activityPlasma antioxidant capacityVitamin E/Significant increaseEndogenous antioxidant systemNon-toxic dosesDose-dependent mannerTotal antioxidant capacitySerum levelsSame dosesBody weightNontoxic dosesWeeksControl levelsTime-dependent regulationAntioxidant defenseDosesSuperoxide dismutaseRatsAntioxidant system