2008
Ethyl pyruvate reduces germ cell–specific apoptosis and oxidative stress in rat model of testicular torsion/detorsion
Payabvash S, Kiumehr S, Tavangar SM, Dehpour AR. Ethyl pyruvate reduces germ cell–specific apoptosis and oxidative stress in rat model of testicular torsion/detorsion. Journal Of Pediatric Surgery 2008, 43: 705-712. PMID: 18405719, DOI: 10.1016/j.jpedsurg.2007.12.063.Peer-Reviewed Original ResearchConceptsEthyl pyruvate solutionRinger's ethyl pyruvate solutionProtective effectRight testisTissue damageMPO activityTesticular torsionGroup 2Sperm countGerm cell apoptosis indicesLong-term testicular functionTesticular torsion/detorsionGerm cell-specific apoptosisLipid peroxidationApoptotic tissue damageTestis tissue damageTorsion/detorsionGroup 2 ratsAnti-inflammatory propertiesSprague-Dawley ratsGroup 24 hoursEpididymal sperm concentrationEthyl pyruvateCell apoptosis indexPyruvate solution
2007
Salutary Effects of N-Acetylcysteine on Apoptotic Damage in a Rat Model of Testicular Torsion
Payabvash S, Salmasi AH, Kiumehr S, Tavangar SM, Nourbakhsh B, Faghihi SH, Dehpour AR. Salutary Effects of N-Acetylcysteine on Apoptotic Damage in a Rat Model of Testicular Torsion. Urologia Internationalis 2007, 79: 248-254. PMID: 17940358, DOI: 10.1159/000107958.Peer-Reviewed Original ResearchConceptsAdministration of NACGerm cell apoptosis indicesIschemia/reperfusion injuryTorsion/detorsionCell apoptosis indexRat modelN-acetylcysteineApoptosis indexReperfusion injuryTesticular torsionProtective effectGroup 2Control groupTesticular torsion/detorsionNAC 30 minRenal tissue damageSprague-Dawley ratsGroup 1 animalsGerm cell apoptosisIntraperitoneal injectionSham operationSaline injectionSystemic administrationTherapeutic doseAntioxidant balance
2005
Effect of morphine on ischemia-reperfusion injury: Experimental study in testicular torsion rat model
Salmasi AH, Beheshtian A, Payabvash S, Demehri S, Ebrahimkhani MR, Karimzadegan M, Bahadori M, Pasalar P, Dehpour AR. Effect of morphine on ischemia-reperfusion injury: Experimental study in testicular torsion rat model. Urology 2005, 66: 1338-1342. PMID: 16360480, DOI: 10.1016/j.urology.2005.06.101.Peer-Reviewed Original ResearchConceptsMorphine groupEffects of morphineTesticular torsionD groupMorphine sulfateBaseline groupMalondialdehyde levelsRight testis 720 degreesAdult male Sprague-DawleyBasal normal valuesHours of detorsionIntravenous morphine sulfateIschemia-reperfusion injurySham-operated groupTesticular malondialdehyde levelsUnilateral testicular torsionMale Sprague-DawleySimilar histopathologic changesNaltrexone groupReperfusion injuryReperfusion phaseHistopathologic changesOpioid receptorsTesticular ischemiaIpsilateral testis