2006
Chronic morphine treatment induces oxidant and apoptotic damage in the mice liver
Payabvash S, Beheshtian A, Salmasi AH, Kiumehr S, Ghahremani MH, Tavangar SM, Sabzevari O, Dehpour AR. Chronic morphine treatment induces oxidant and apoptotic damage in the mice liver. Life Sciences 2006, 79: 972-980. PMID: 16750225, DOI: 10.1016/j.lfs.2006.05.008.Peer-Reviewed Original ResearchConceptsChronic morphine treatmentMorphine treatmentMorphine administrationHigh dosesInduction of apoptosisInduction of liverHepatic glutathione concentrationAntioxidant defenseLiver antioxidant defensesObserved adverse effectsPro-oxidant effectsCancer painEnzymatic antioxidant defensesOpioid analgesicsChronic painOpioid drugsTumor spreadOpioid receptorsSame dosesHepatotoxic effectsProtective roleTumor growthLow dosesMorphineHepatocyte apoptosis
2005
Effect of morphine on ischemia-reperfusion injury: Experimental study in testicular torsion rat model
Salmasi AH, Beheshtian A, Payabvash S, Demehri S, Ebrahimkhani MR, Karimzadegan M, Bahadori M, Pasalar P, Dehpour AR. Effect of morphine on ischemia-reperfusion injury: Experimental study in testicular torsion rat model. Urology 2005, 66: 1338-1342. PMID: 16360480, DOI: 10.1016/j.urology.2005.06.101.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsMaleMorphineRatsRats, Sprague-DawleyReperfusion InjurySpermatic Cord TorsionTestisConceptsMorphine groupEffects of morphineTesticular torsionD groupMorphine sulfateBaseline groupMalondialdehyde levelsRight testis 720 degreesAdult male Sprague-DawleyBasal normal valuesHours of detorsionIntravenous morphine sulfateIschemia-reperfusion injurySham-operated groupTesticular malondialdehyde levelsUnilateral testicular torsionMale Sprague-DawleySimilar histopathologic changesNaltrexone groupReperfusion injuryReperfusion phaseHistopathologic changesOpioid receptorsTesticular ischemiaIpsilateral testis