Featured Publications
Prevalence of Missing Data in the National Cancer Database and Association With Overall Survival
Yang DX, Khera R, Miccio JA, Jairam V, Chang E, Yu JB, Park HS, Krumholz HM, Aneja S. Prevalence of Missing Data in the National Cancer Database and Association With Overall Survival. JAMA Network Open 2021, 4: e211793. PMID: 33755165, PMCID: PMC7988369, DOI: 10.1001/jamanetworkopen.2021.1793.Peer-Reviewed Original ResearchConceptsNational Cancer DatabaseNon-small cell lung cancerOverall survivalCell lung cancerCancer DatabaseMedical recordsLung cancerProstate cancerBreast cancerPatient recordsComplete dataRetrospective cohort studyCohort studyCancer RegistryCommon cancerVariables of interestHigh prevalenceMAIN OUTCOMEPatientsClinical advancementReal-world data sourcesCancerPrevalenceSurvivalHeterogeneous differencesPremetastatic shifts of endogenous and exogenous mutational processes support consolidative therapy in EGFR-driven lung adenocarcinoma
Fisk JN, Mahal AR, Dornburg A, Gaffney SG, Aneja S, Contessa JN, Rimm D, Yu JB, Townsend JP. Premetastatic shifts of endogenous and exogenous mutational processes support consolidative therapy in EGFR-driven lung adenocarcinoma. Cancer Letters 2021, 526: 346-351. PMID: 34780851, PMCID: PMC8702484, DOI: 10.1016/j.canlet.2021.11.011.Peer-Reviewed Original ResearchConceptsMutational processesSingle ancestral lineageAncestral lineageProgression of cancerMetastatic lineagesPhylogenetic analysisGenetic resistanceEvolutionary processesExogenous mutational processesCancer evolutionConsolidative therapyMutational signature analysisEGFR-positive non-small cell lung cancerNon-small cell lung cancerKey eventsLineagesCell populationsTherapeutic resistanceLocal consolidative therapyClinical time courseCell lung cancerDisease etiologyTherapeutic decision makingCisplatin therapyLung cancer
2024
A Comparison of Machine Learning Models to Predict Lymph Node Metastasis with Primary Tumor Transcriptome in Non-Small Cell Lung Cancer
Lee V, Park H, Aneja S, Patel A. A Comparison of Machine Learning Models to Predict Lymph Node Metastasis with Primary Tumor Transcriptome in Non-Small Cell Lung Cancer. International Journal Of Radiation Oncology • Biology • Physics 2024, 120: e638. DOI: 10.1016/j.ijrobp.2024.07.1402.Peer-Reviewed Original ResearchNon-small cell lung cancerLymph nodal metastasisCell lung cancerMedian AUCNodal metastasisPrimary tumorEndobronchial ultrasoundNon-small cell lung cancer stagingLung cancerDiagnostic uncertaintyPrediction of nodal metastasisPET-avid lesionsTreatment strategy formulationPrimary lung adenocarcinomaEBUS-guided biopsiesLymph node metastasisPrimary tumor tissuesReceiver operating characteristic curveTumor transcriptomic dataPET-CTNode metastasisNeedle aspirationCT scanNon-smallClinical decision-makingApplying Language Models to Radiology Text for Identifying Oligometastatic Non-Small Cell Lung Cancer
Moore N, Laird J, Verma N, Hager T, Sritharan D, Lee V, Maresca R, Chadha S, Park H, Aneja S. Applying Language Models to Radiology Text for Identifying Oligometastatic Non-Small Cell Lung Cancer. International Journal Of Radiation Oncology • Biology • Physics 2024, 120: e644. DOI: 10.1016/j.ijrobp.2024.07.1417.Peer-Reviewed Original ResearchNon-small cell lung cancerOligometastatic diseaseCell lung cancerRadiologic impressionTumor RegistryTest cohortOligometastatic non-small cell lung cancerIV non-small cell lung cancerStage IV non-small cell lung cancerLung cancerConvolutional neural networkMetastasis-directed therapyOligometastatic NSCLC patientsMonths of diagnosisLanguage modelClinician reviewNSCLC patientsPatient cohortClinical dataScreening patientsSubgroup analysisBrain MRIClinical textBurden of diseaseClinical relevanceLymph node metastasis prediction with non-small cell lung cancer histopathology imaging.
Lee V, King A, Sritharan D, Moore N, Chadha S, Maresca R, Hager T, Aneja S. Lymph node metastasis prediction with non-small cell lung cancer histopathology imaging. Journal Of Clinical Oncology 2024, 42: 8063-8063. DOI: 10.1200/jco.2024.42.16_suppl.8063.Peer-Reviewed Original ResearchNon-small cell lung cancerLymph nodal metastasisNational Lung Screening TrialLymph node metastasisNodal metastasisNode metastasisEndobronchial ultrasound-guided transbronchial needle aspirationUltrasound-guided transbronchial needle aspirationTreatment strategy formulationTransbronchial needle aspirationCell lung cancerDistant metastasis statusLymph node metastasis predictionPrimary tumor dataHematoxylin and eosin (H&EInvasive diagnostic techniquesInfluence clinical decisionsN0 diseaseN3 diseaseEosin (H&EPrimary resectionDistant metastasisPET-CTNeedle aspirationCT scan