2013
Anatomic Considerations in the Surgical Resection of Hepatocellular Carcinoma
Yoo PS, Enestvedt CK, Kulkarni S. Anatomic Considerations in the Surgical Resection of Hepatocellular Carcinoma. Journal Of Clinical Gastroenterology 2013, 47: s11-s15. PMID: 23632343, DOI: 10.1097/mcg.0b013e318280ce5f.Peer-Reviewed Original ResearchConceptsOrthotopic liver transplantationSurgical resectionHepatocellular carcinomaNonanatomic resectionLiver transplantationTreatment of HCCFormal anatomic resectionInferior oncologic outcomesResidual liver massExtent of resectionCommon primary malignancyFunctional hepatic parenchymaRelevant surgical anatomyLocoregional therapySystemic chemotherapyAnatomic resectionHepatic resectionOncologic outcomesPrimary malignancyCancer deathHepatic parenchymaSurgical techniqueCommon causeAdvanced casesResection
2012
Intermedin is overexpressed in hepatocellular carcinoma and regulates cell proliferation and survival
Guo X, Schmitz JC, Kenney BC, Uchio EM, Kulkarni S, H. CH. Intermedin is overexpressed in hepatocellular carcinoma and regulates cell proliferation and survival. Cancer Science 2012, 103: 1474-1480. PMID: 22625651, PMCID: PMC7659195, DOI: 10.1111/j.1349-7006.2012.02341.x.Peer-Reviewed Original ResearchConceptsHepatocellular carcinomaCell proliferationHepatocellular carcinoma (HCC) clinical samplesRat ischemic modelEarly-stage diseaseHuman hepatocellular carcinoma tumorsSNU-398 cellsHuman umbilical vascular endothelial cellsRole of intermedinDownregulation of Gli1Real-time RT-PCRDose-dependent mannerHepatocellular carcinoma tumorsVascular endothelial cellsMRNA expression levelsStage diseaseExtracellular signal-regulated kinaseSK-Hep-1Ischemic modelIMD expressionBenign liverCarcinoma tumorsImmunohistochemical analysisTherapeutic targetSignal-regulated kinase