2013
Rapamycin-treated human endothelial cells preferentially activate allogeneic regulatory T cells
Wang C, Yi T, Qin L, Maldonado RA, von Andrian UH, Kulkarni S, Tellides G, Pober JS. Rapamycin-treated human endothelial cells preferentially activate allogeneic regulatory T cells. Journal Of Clinical Investigation 2013, 123: 1677-1693. PMID: 23478407, PMCID: PMC3613923, DOI: 10.1172/jci66204.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsArteriesB7-H1 AntigenCD4-Positive T-LymphocytesCell ProliferationCells, CulturedCoculture TechniquesFemaleGene ExpressionGene Knockdown TechniquesHuman Umbilical Vein Endothelial CellsHumansImmunosuppression TherapyInterleukin-6Lymphocyte ActivationMiceMice, SCIDProgrammed Cell Death 1 Ligand 2 ProteinRegulatory-Associated Protein of mTORRNA, Small InterferingSirolimusT-Lymphocytes, RegulatoryTOR Serine-Threonine KinasesTranscriptional ActivationTransplantation, HomologousConceptsEffect of rapamycinT cellsEndothelial cellsAllograft rejectionHuman endothelial cellsPD-L1PD-L2Allogeneic regulatory T cellsHuman-mouse chimeric modelInhibitory molecule PD-L1Inflammatory cytokines IL-6Alloantigen-specific mannerAllograft endothelial cellsHuman arterial allograftsImmune-mediated rejectionGraft endothelial cellsEffector T cellsRegulatory T cellsMemory T cellsT cell responsesAntigen-presenting cellsCytokines IL-6Mock-treated cellsAllogeneic CD4Effector cytokines
2010
KDOQI US Commentary on the 2009 KDIGO Clinical Practice Guideline for the Care of Kidney Transplant Recipients
Bia M, Adey DB, Bloom RD, Chan L, Kulkarni S, Tomlanovich S. KDOQI US Commentary on the 2009 KDIGO Clinical Practice Guideline for the Care of Kidney Transplant Recipients. American Journal Of Kidney Diseases 2010, 56: 189-218. PMID: 20598411, DOI: 10.1053/j.ajkd.2010.04.010.Peer-Reviewed Original ResearchMeSH KeywordsClinical ProtocolsCreatinineGlomerular Filtration RateGlucocorticoidsHumansImmunocompromised HostImmunosuppression TherapyKidney DiseasesKidney TransplantationLife StyleLip NeoplasmsMonitoring, PhysiologicNeoplasmsPostoperative CarePractice Guidelines as TopicSkin NeoplasmsTransplantation, HomologousUnited StatesConceptsKidney transplant recipientsKidney Foundation Kidney Disease Outcomes Quality InitiativeKidney Disease Outcomes Quality InitiativeKDIGO guidelinesTransplant recipientsNational Kidney Foundation Kidney Disease Outcomes Quality InitiativeUS kidney transplant recipientsKDIGO Clinical Practice GuidelineKDOQI US CommentaryClinical practice guidelinesSpecific patient populationsKDIGO recommendationsPosttransplant periodTransplant careTransplant centersUS patientsPatient populationTransplant nephrologistsPractice guidelinesCardiovascular careTransplant guidelinesLifestyle changesComplex careExcellent road mapCare