P37 Convergent somatic mutations in effectors of insulin signalling in chronic liver disease
Ng S, Brunner S, Brzozowska N, Aitken S, Abascal F, Moore L, Leongamornlert D, Ivovic A, Robinson P, Butler T, Sanders M, Williams N, Coorens T, Teague J, Raine K, Butler A, Hooks Y, Wilson B, Birtchnell N, Naylor H, Davies S, Stratton M, Martincorena I, Hoare M, Campbell P. P37 Convergent somatic mutations in effectors of insulin signalling in chronic liver disease. Gut 2020, 69: a25-a25. DOI: 10.1136/gutjnl-2020-basl.47.Peer-Reviewed Original ResearchChronic liver diseaseLiver diseaseSomatic mutationsAssociated with metabolic dysregulationSystemic metabolic dysfunctionNon-alcoholic fatty liver diseaseFatty liver diseaseInsulin signalingEffectors of insulin signalingLiver failureHepatocellular carcinomaMultiple independent acquisitionsGram of tissueDownstream of insulin signalingMetabolic dysfunctionMetabolic dysregulationNormal controlsPatient samplesLiver samplesExcess of mutationsNormal liverDietary caloriesLiverAlcohol-relatedDisease