β2-Adrenoreceptor ligands regulate osteoclast differentiation in vitro by direct and indirect mechanisms
Aitken S, Landao-Bassonga E, Ralston S, Idris A. β2-Adrenoreceptor ligands regulate osteoclast differentiation in vitro by direct and indirect mechanisms. Archives Of Biochemistry And Biophysics 2008, 482: 96-103. PMID: 19059194, DOI: 10.1016/j.abb.2008.11.012.Peer-Reviewed Original ResearchConceptsExpression of RANK-LBeta2-adrenoceptorOsteoclast formationBeta-adrenoceptorIncreased expression of RANK-LBone resorptionInfluence bone mineral densityOsteoclast differentiation in vitroRegulation of bone massBone mineral densityEffect of noradrenalineRANK-LSympathetic nervous systemInduce osteoclast formationOsteoblasts co-culturedDifferentiation in vitroAgonist isoprenalineMineral densityBeta3-adrenoceptorFracture riskLevels of beta1Beta-adrenoreceptorsBone massPharmacological agonistsOsteoblast growth