Successful transmission and transcriptional deployment of a human chromosome via mouse male meiosis
Ernst C, Pike J, Aitken S, Long H, Eling N, Stojic L, Ward M, Connor F, Rayner T, Lukk M, Klose R, Kutter C, Odom D. Successful transmission and transcriptional deployment of a human chromosome via mouse male meiosis. ELife 2016, 5: e20235. PMID: 27855777, PMCID: PMC5161449, DOI: 10.7554/elife.20235.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsChromosomes, HumanCytogenetic AnalysisGerm CellsHumansMaleMeiosisMiceTranscription, GeneticConceptsHuman chromosomeMale meiosisTranscription factor bindingGermline transmissionNon-methylated DNATolerance of aneuploidyStudy chromosomal abnormalitiesMammalian spermatogenesisMapped transcriptsTranscription initiationFactor bindingDevelopmental machineryChromatin condensationTestis architectureAneuploid miceExogenous DNAAneuploid offspringMale sterilityChromosomeAdult tissuesSpermatogenesisMeiosisChromosomal abnormalitiesEnhanced activityTranscription