Featured Publications
Titration of RAS alters senescent state and influences tumour initiation
Chan A, Zhu H, Narita M, Cassidy L, Young A, Bermejo-Rodriguez C, Janowska A, Chen H, Gough S, Oshimori N, Zender L, Aitken S, Hoare M, Narita M. Titration of RAS alters senescent state and influences tumour initiation. Nature 2024, 633: 678-685. PMID: 39112713, PMCID: PMC11410659, DOI: 10.1038/s41586-024-07797-z.Peer-Reviewed Original ResearchConceptsTumor typesOncogenic RAS-induced senescenceInfluence tumor initiationProgenitor-like featuresTumor-initiating phenotypeSingle-cell RNA sequencing analysisModel in vivoHCC subclassesModel in vitroHepatocellular carcinomaTumor suppressor mechanismEarly tumorigenesisTumor initiationEarly-onsetProgenitor featuresInduce tumorsSuppressor mechanismTumorLate-onsetRNA sequencing analysisOncogenic stressRas-induced senescenceIn vivoMolecular signaturesOncogene dosagePervasive lesion segregation shapes cancer genome evolution
Aitken S, Anderson C, Connor F, Pich O, Sundaram V, Feig C, Rayner T, Lukk M, Aitken S, Luft J, Kentepozidou E, Arnedo-Pac C, Beentjes S, Davies S, Drews R, Ewing A, Kaiser V, Khamseh A, López-Arribillaga E, Redmond A, Santoyo-Lopez J, Sentís I, Talmane L, Yates A, Semple C, López-Bigas N, Flicek P, Odom D, Taylor M. Pervasive lesion segregation shapes cancer genome evolution. Nature 2020, 583: 265-270. PMID: 32581361, PMCID: PMC7116693, DOI: 10.1038/s41586-020-2435-1.Peer-Reviewed Original ResearchConceptsChromosome-scale phasingDNA lesionsAcquisition of oncogenic mutationsAlternative allelesGenetic diversityMultiple cell generationsCancer genomesLesion segregationDNA replicationMutagenic DNA lesionsDaughter cellsBase pairsCell divisionCell cycleExogenous mutagensHuman cellsOncogenic selectionOncogenic mutationsMouse liver tumorsDNACell generationDNA base pairsMutationsCellsGenome
2011
Accuracy of hepatocellular carcinoma detection on multidetector CT in a transplant liver population with explant liver correlation
Addley H, Griffin N, Shaw A, Mannelli L, Parker R, Aitken S, Wood H, Davies S, Alexander G, Lomas D. Accuracy of hepatocellular carcinoma detection on multidetector CT in a transplant liver population with explant liver correlation. Clinical Radiology 2011, 66: 349-356. PMID: 21295772, DOI: 10.1016/j.crad.2010.11.012.Peer-Reviewed Original ResearchConceptsDetection of HCC lesionsMultidetector computed tomographyHepatocellular carcinomaMDCT examinationsHCC lesionsLiver transplantationDiagnostic confidenceDiagnostic accuracyDiagnostic accuracy of multidetector computed tomographyAccuracy of multidetector computed tomographySize of hepatocellular carcinomaLesion sizeDetection of hepatocellular carcinomaFive-point confidence scaleHepatocellular carcinoma detectionHelical CT imagesEffect of radiologist experienceLiver populationMultidetector CTCirrhotic patientsHistopathological correlationHistopathological resultsComputed tomographyCarcinoma detectionRadiologist experience