2024
β‑Amino Acids Reduce Ternary Complex Stability and Alter the Translation Elongation Mechanism
Cruz-Navarrete F, Griffin W, Chan Y, Martin M, Alejo J, Brady R, Natchiar S, Knudson I, Altman R, Schepartz A, Miller S, Blanchard S. β‑Amino Acids Reduce Ternary Complex Stability and Alter the Translation Elongation Mechanism. ACS Central Science 2024, 10: 1262-1275. PMID: 38947208, PMCID: PMC11212133, DOI: 10.1021/acscentsci.4c00314.Peer-Reviewed Original ResearchNon-natural amino acidsComplex stabilityTernary complex stabilityTemplate synthesisDetection limitEnergy transfer measurementsTernary complex formationComplex formationSingle-molecule fluorescence resonance energy transfer measurementsIn vitro detection limitTernary complexFluorescence resonance energy transfer measurementsAmino acidsMechanism of protein synthesisResonance energy transfer measurementsSynthesis of proteinsRate of translocationMRNA decodingElongation substratesStabilityElongation factorIsomersRibosome utilizationAminoacyl-tRNAStereoisomers
2016
Synthesis and evaluation of phenylalanine-derived trifluoromethyl ketones for peptide-based oxidation catalysis
Featherston AL, Miller SJ. Synthesis and evaluation of phenylalanine-derived trifluoromethyl ketones for peptide-based oxidation catalysis. Bioorganic & Medicinal Chemistry 2016, 24: 4871-4874. PMID: 27452284, PMCID: PMC5053897, DOI: 10.1016/j.bmc.2016.07.012.Peer-Reviewed Original Research
2014
Diastereo- and Enantioselective Addition of Anilide-Functionalized Allenoates to N‑Acylimines Catalyzed by a Pyridylalanine-Based Peptide
Mbofana CT, Miller SJ. Diastereo- and Enantioselective Addition of Anilide-Functionalized Allenoates to N‑Acylimines Catalyzed by a Pyridylalanine-Based Peptide. Journal Of The American Chemical Society 2014, 136: 3285-3292. PMID: 24527787, DOI: 10.1021/ja412996f.Peer-Reviewed Original Research