2016
From substituent effects to applications: enhancing the optical response of a four-component assembly for reporting ee values
Lin CY, Giuliano MW, Ellis BD, Miller SJ, Anslyn EV. From substituent effects to applications: enhancing the optical response of a four-component assembly for reporting ee values. Chemical Science 2016, 7: 4085-4090. PMID: 27904740, PMCID: PMC5125730, DOI: 10.1039/c5sc04629g.Peer-Reviewed Original ResearchMulticomponent assembliesFour-component assemblySubstituent effect studiesPyridyl ligandsAsymmetric catalystsPyridyl-3High-throughput screeningSteric effectsCD signalSecondary alcoholsSubstituent effectsStandard HPLC analysisMode of interactionEe valuesSubstituent sizeCalibration curveNew assemblyOptical responseAssemblyHPLC analysis
2015
Phosphothreonine as a Catalytic Residue in Peptide‐Mediated Asymmetric Transfer Hydrogenations of 8‐Aminoquinolines
Shugrue CR, Miller SJ. Phosphothreonine as a Catalytic Residue in Peptide‐Mediated Asymmetric Transfer Hydrogenations of 8‐Aminoquinolines. Angewandte Chemie International Edition 2015, 54: 11173-11176. PMID: 26246129, PMCID: PMC4628550, DOI: 10.1002/anie.201505898.Peer-Reviewed Original ResearchConceptsTransfer hydrogenationChiral phosphoric acid catalystHydrogen bonding interactionsPhosphoric acid catalystAsymmetric transfer hydrogenationEnantioselective transfer hydrogenationAsymmetric catalystsAcid catalystStrong complexationNMR studiesSubstrate classesCatalystHydrogenationNew classCatalytic residuesPeptidesComplexationEnantioselectivityQuinolinePhosphopeptidesSubstrateResidues