2017
A bottom up approach towards artificial oxygenases by combining iron coordination complexes and peptides
Cussó O, Giuliano MW, Ribas X, Miller SJ, Costas M. A bottom up approach towards artificial oxygenases by combining iron coordination complexes and peptides. Chemical Science 2017, 8: 3660-3667. PMID: 29270284, PMCID: PMC5734052, DOI: 10.1039/c7sc00099e.Peer-Reviewed Original ResearchIron centerHigh enantioselectivityIron coordination complexesAqueous hydrogen peroxideSecond coordination sphereΒ-turn structureShort reaction timesTerminal carboxylic acidSupramolecular catalystsCoordination complexesSupramolecular systemsClasses of substratesAsymmetric catalysisCoordination sphereAsymmetric epoxidationExcellent yieldsCarboxylic acidsCombination of peptidesActivation stepHydrogen peroxideReaction timeEpoxidationEnantioselectivityPeptidesCatalyst
2013
Combined Lewis acid and Brønsted acid-mediated reactivity of glycosyl trichloroacetimidate donors
Gould ND, Allen C, Nam BC, Schepartz A, Miller SJ. Combined Lewis acid and Brønsted acid-mediated reactivity of glycosyl trichloroacetimidate donors. Carbohydrate Research 2013, 382: 36-42. PMID: 24177201, DOI: 10.1016/j.carres.2013.09.011.Peer-Reviewed Original ResearchConceptsLewis acidGlycosylation reactionsCombined Lewis acidControl reactionsSubsequent kinetic studiesCatalytic systemBiomimetic conditionsCarboxylic acidsGlycosyl donorsIrreversible reactionKinetic studiesReactionAcid actsCatalytic componentAcidActive enzymeCarbohydrate-active enzymesCatalystProof of principleReactivityDonorsGlycosylStructure