Applications of Nonenzymatic Catalysts to the Alteration of Natural Products
Shugrue CR, Miller SJ. Applications of Nonenzymatic Catalysts to the Alteration of Natural Products. Chemical Reviews 2017, 117: 11894-11951. PMID: 28580785, PMCID: PMC5742423, DOI: 10.1021/acs.chemrev.7b00022.Peer-Reviewed Original ResearchConceptsNatural productsNonenzymatic catalystsComplex molecular scaffoldsComplex natural productsH bond functionalizationC bond formationNatural product scaffoldsLate-stage functionalizationNatural product derivativesSynthesis of analoguesChemical functionalityMedicinal chemistryBond functionalizationElectrophilic reagentsOlefin functionalizationSelectivity challengesBiological activity assaysBond formationEnzymatic catalystsProduct derivativesMolecular scaffoldsCatalystComplex moleculesChemical remodelingSmall molecules