2017
Identification and Partial Structural Characterization of Mass Isolated Valsartan and Its Metabolite with Messenger Tagging Vibrational Spectroscopy
Gorlova O, Colvin SM, Brathwaite A, Menges FS, Craig SM, Miller SJ, Johnson MA. Identification and Partial Structural Characterization of Mass Isolated Valsartan and Its Metabolite with Messenger Tagging Vibrational Spectroscopy. Journal Of The American Society For Mass Spectrometry 2017, 28: 2414-2422. PMID: 28801884, DOI: 10.1007/s13361-017-1767-z.Peer-Reviewed Original ResearchVibrational spectroscopyStructural characterizationRole of conformersOH stretching fundamentalsPartial structural characterizationStructural isomersIsomeric formsTarget ionsMass spectrometryN2 moleculesDrug valsartanRf ion trapIR absorptionIon trapFingerprint regionK ionsIon approachSpectroscopyIonsIsomersCharacterizationConformersRecent advancesSpectrometryOH
2013
Asymmetric Catalysis at a Distance: Catalytic, Site-Selective Phosphorylation of Teicoplanin
Han S, Miller SJ. Asymmetric Catalysis at a Distance: Catalytic, Site-Selective Phosphorylation of Teicoplanin. Journal Of The American Chemical Society 2013, 135: 12414-12421. PMID: 23924210, PMCID: PMC3790668, DOI: 10.1021/ja406067v.Peer-Reviewed Original ResearchConceptsTeicoplanin A2-2Site-selective phosphorylationPeptide-based catalystsSmall-molecule catalystsX-ray crystal structureCatalyst-substrate interactionsSet of catalystsDistinct hydroxyl groupsAsymmetric catalysisCatalytic controlStructural assignmentCatalystTeicoplanin derivativesNatural productsGlycopeptide structuresHydroxyl groupsCrystal structureMass spectrometryMechanistic studiesBiological activityCatalytic moietyAdditional functionalityCatalysisMoietySpectroscopy