Scaffold‐Oriented Asymmetric Catalysis: Conformational Modulation of Transition State Multivalency during a Catalyst‐Controlled Assembly of a Pharmaceutically Relevant Atropisomer
Tampellini N, Mercado B, Miller S. Scaffold‐Oriented Asymmetric Catalysis: Conformational Modulation of Transition State Multivalency during a Catalyst‐Controlled Assembly of a Pharmaceutically Relevant Atropisomer. Chemistry - A European Journal 2024, 30: e202401109. PMID: 38507249, PMCID: PMC11132932, DOI: 10.1002/chem.202401109.Peer-Reviewed Original ResearchHydrogen bond donorAtroposelective synthesisAsymmetric catalysisGuanidine catalystCatalyst controlChiral axisBond donorNoncovalent interactionsConformational modulationCatalystFolded stateN-capAtroposelectivityAtropisomersSuperbasesPhenylCatalysisQuinazolinedionesMultivalencyBTK inhibitorsMechanistic frameworkStructure