2016
d-3-Deoxy-dioctanoylphosphatidylinositol induces cytotoxicity in human MCF-7 breast cancer cells via a mechanism that involves downregulation of the D-type cyclin-retinoblastoma pathway
Gradziel CS, Jordan PA, Jewel D, Dufort FJ, Miller SJ, Chiles TC, Roberts MF. d-3-Deoxy-dioctanoylphosphatidylinositol induces cytotoxicity in human MCF-7 breast cancer cells via a mechanism that involves downregulation of the D-type cyclin-retinoblastoma pathway. Biochimica Et Biophysica Acta 2016, 1861: 1808-1815. PMID: 27600289, PMCID: PMC5115159, DOI: 10.1016/j.bbalip.2016.09.001.Peer-Reviewed Original ResearchMeSH KeywordsBreast NeoplasmsCell DeathCyclin D1Down-RegulationFemaleHumansMagnetic Resonance SpectroscopyMCF-7 CellsP38 Mitogen-Activated Protein KinasesPhosphatidic AcidsPhosphatidylinositolsPhosphorylationPleckstrin Homology DomainsProto-Oncogene Proteins c-aktRetinoblastoma ProteinRNA, Small InterferingSignal TransductionConceptsMCF-7 breast cancer cellsBreast cancer cellsAkt PH domainPhosphatidylinositol analoguesD-type cyclinsCancer cellsCyclin D1Cleavage of PARPPH domainProtein phosphorylationMembrane translocationActive AktHuman MCF-7 breast cancer cellsGrowth arrestCaspase-9Endogenous levelsCyclin D3Cell proliferationAlkylphospholipid perifosineMCF-7 cell proliferationAnti-proliferative activityAktPathwayDownregulation
2013
A Fully Synthetic and Biochemically Validated Phosphatidyl Inositol-3-Phosphate Hapten via Asymmetric Synthesis and Native Chemical Ligation
Chandler BD, Burkhardt AL, Foley K, Cullis C, Driscoll D, D’Amore N, Miller SJ. A Fully Synthetic and Biochemically Validated Phosphatidyl Inositol-3-Phosphate Hapten via Asymmetric Synthesis and Native Chemical Ligation. Journal Of The American Chemical Society 2013, 136: 412-418. PMID: 24344932, PMCID: PMC3919123, DOI: 10.1021/ja410750a.Peer-Reviewed Original ResearchMeSH KeywordsCysteineElectrophoresis, Polyacrylamide GelHaptensInositol PhosphatesPhosphatidylinositols