2014
Spontaneous transfer of chirality in an atropisomerically enriched two-axis system
Barrett KT, Metrano AJ, Rablen PR, Miller SJ. Spontaneous transfer of chirality in an atropisomerically enriched two-axis system. Nature 2014, 509: 71-75. PMID: 24747399, PMCID: PMC4008667, DOI: 10.1038/nature13189.Peer-Reviewed Original Research
2013
Enantioselective Synthesis of Atropisomeric Benzamides through Peptide-Catalyzed Bromination
Barrett KT, Miller SJ. Enantioselective Synthesis of Atropisomeric Benzamides through Peptide-Catalyzed Bromination. Journal Of The American Chemical Society 2013, 135: 2963-2966. PMID: 23410090, PMCID: PMC3596792, DOI: 10.1021/ja400082x.Peer-Reviewed Original ResearchConceptsEnantioselective synthesisElectrophilic aromatic substitution reactionsSeries of triAromatic substitution reactionMetal-halogen exchangeRange of compoundsCatalytic brominationNMR spectroscopySubstitution reactionsBrønsted baseObserved productsOrtho functionalizationTertiary aminesLow conversionSubstitution patternBrominationCatalystHigh barrierBenzamidesReactionTertiary benzamidesAppropriate substrateSynthesisFunctionalizationDibromination