d-3-Deoxy-dioctanoylphosphatidylinositol induces cytotoxicity in human MCF-7 breast cancer cells via a mechanism that involves downregulation of the D-type cyclin-retinoblastoma pathway
Gradziel CS, Jordan PA, Jewel D, Dufort FJ, Miller SJ, Chiles TC, Roberts MF. d-3-Deoxy-dioctanoylphosphatidylinositol induces cytotoxicity in human MCF-7 breast cancer cells via a mechanism that involves downregulation of the D-type cyclin-retinoblastoma pathway. Biochimica Et Biophysica Acta 2016, 1861: 1808-1815. PMID: 27600289, PMCID: PMC5115159, DOI: 10.1016/j.bbalip.2016.09.001.Peer-Reviewed Original ResearchMeSH KeywordsBreast NeoplasmsCell DeathCyclin D1Down-RegulationFemaleHumansMagnetic Resonance SpectroscopyMCF-7 CellsP38 Mitogen-Activated Protein KinasesPhosphatidic AcidsPhosphatidylinositolsPhosphorylationPleckstrin Homology DomainsProto-Oncogene Proteins c-aktRetinoblastoma ProteinRNA, Small InterferingSignal TransductionConceptsMCF-7 breast cancer cellsBreast cancer cellsAkt PH domainPhosphatidylinositol analoguesD-type cyclinsCancer cellsCyclin D1Cleavage of PARPPH domainProtein phosphorylationMembrane translocationActive AktHuman MCF-7 breast cancer cellsGrowth arrestCaspase-9Endogenous levelsCyclin D3Cell proliferationAlkylphospholipid perifosineMCF-7 cell proliferationAnti-proliferative activityAktPathwayDownregulation