2008
Autoreactive B Cells Discriminate CpG-Rich and CpG-Poor DNA and This Response Is Modulated by IFN-α
Uccellini MB, Busconi L, Green NM, Busto P, Christensen SR, Shlomchik MJ, Marshak-Rothstein A, Viglianti GA. Autoreactive B Cells Discriminate CpG-Rich and CpG-Poor DNA and This Response Is Modulated by IFN-α. The Journal Of Immunology 2008, 181: 5875-5884. PMID: 18941176, PMCID: PMC2584609, DOI: 10.4049/jimmunol.181.9.5875.Peer-Reviewed Original ResearchConceptsAutoreactive B cellsDNA-reactive B cellsB cellsImmune complexesIFN-alphaLow-affinity autoreactive B cellsSystemic lupus erythematosusB cell proliferationBCR transgenic miceTLR9-dependent activationLupus erythematosusUnmethylated CpG dinucleotideTransgenic miceImmunostimulatory motifsCell proliferationActivation thresholdTLR9Normal repertoireCellsPotent ligandsBCRCpG island fragmentsDual engagementActivationImportant mechanism
2006
Toll-like Receptor 7 and TLR9 Dictate Autoantibody Specificity and Have Opposing Inflammatory and Regulatory Roles in a Murine Model of Lupus
Christensen SR, Shupe J, Nickerson K, Kashgarian M, Flavell RA, Shlomchik MJ. Toll-like Receptor 7 and TLR9 Dictate Autoantibody Specificity and Have Opposing Inflammatory and Regulatory Roles in a Murine Model of Lupus. Immunity 2006, 25: 417-428. PMID: 16973389, DOI: 10.1016/j.immuni.2006.07.013.Peer-Reviewed Original ResearchConceptsLupus-prone miceSystemic lupus erythematosusAutoimmune diseasesToll-like receptor 7Toll-like receptor 9Absence of TLR9TLR7-deficient miceDevelopment of lupusPlasmacytoid DCsLupus erythematosusSerum IgGSusceptible miceAutoantibody specificitiesReceptor 7Receptor 9DNA autoantibodiesClinical diseaseIFN-alphaMurine modelLymphocyte activationTLR7TLR9Regulatory roleDiseaseMice