2009
RAGE-independent autoreactive B cell activation in response to chromatin and HMGB1/DNA immune complexes
Avalos AM, Kiefer K, Tian J, Christensen S, Shlomchik M, Coyle AJ, Marshak-Rothstein A. RAGE-independent autoreactive B cell activation in response to chromatin and HMGB1/DNA immune complexes. Autoimmunity 2009, 43: 103-110. PMID: 20014975, PMCID: PMC2929824, DOI: 10.3109/08916930903384591.Peer-Reviewed Original ResearchConceptsAM14 B cellsB cell activationHMGB1-DNA complexHMGB1-RAGE interactionNuclear DNACell activationAutoreactive B cell activationB cell responsesB cellsDNA immune complexesImmune complexesSoluble formRole of HMGB1DNAAutoreactive B cell responsesCell responsesCell debrisCellsCellular debrisExcessive accumulationRAGE-deficient miceSystemic autoimmune diseaseActivationRole of RAGETLR9-dependent manner
2005
Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus
Christensen SR, Kashgarian M, Alexopoulou L, Flavell RA, Akira S, Shlomchik MJ. Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus. Journal Of Experimental Medicine 2005, 202: 321-331. PMID: 16027240, PMCID: PMC2212997, DOI: 10.1084/jem.20050338.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, AntinuclearAntibody FormationAutoantigensAutoimmunityB-LymphocytesDNADNA-Binding ProteinsHumansImmunity, InnateLupus NephritisMembrane GlycoproteinsMiceMice, KnockoutReceptors, Cell SurfaceRibonucleoproteins, Small NuclearSnRNP Core ProteinsToll-Like Receptor 3Toll-Like Receptor 9Toll-Like ReceptorsConceptsToll-like receptor 9TLR9-deficient miceAutoantibody productionAutoimmune diseasesReceptor 9Clinical autoimmune diseaseDNA-containing antigensSelf-nuclear antigensAnti-DNA autoantibody productionAnti-dsDNA autoantibodiesLupus-prone miceSystemic lupus erythematosusFormation of autoantibodiesSystemic autoimmune diseaseInnate immune activationAutoreactive B cellsLupus erythematosusAutoantibody formationMurine lupusImmune activationImmunologic toleranceAntichromatin autoantibodiesSmith antigenCpG DNAB cells