2008
Autoreactive B Cells Discriminate CpG-Rich and CpG-Poor DNA and This Response Is Modulated by IFN-α
Uccellini MB, Busconi L, Green NM, Busto P, Christensen SR, Shlomchik MJ, Marshak-Rothstein A, Viglianti GA. Autoreactive B Cells Discriminate CpG-Rich and CpG-Poor DNA and This Response Is Modulated by IFN-α. The Journal Of Immunology 2008, 181: 5875-5884. PMID: 18941176, PMCID: PMC2584609, DOI: 10.4049/jimmunol.181.9.5875.Peer-Reviewed Original ResearchConceptsAutoreactive B cellsDNA-reactive B cellsB cellsImmune complexesIFN-alphaLow-affinity autoreactive B cellsSystemic lupus erythematosusB cell proliferationBCR transgenic miceTLR9-dependent activationLupus erythematosusUnmethylated CpG dinucleotideTransgenic miceImmunostimulatory motifsCell proliferationActivation thresholdTLR9Normal repertoireCellsPotent ligandsBCRCpG island fragmentsDual engagementActivationImportant mechanism
2005
Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus
Christensen SR, Kashgarian M, Alexopoulou L, Flavell RA, Akira S, Shlomchik MJ. Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus. Journal Of Experimental Medicine 2005, 202: 321-331. PMID: 16027240, PMCID: PMC2212997, DOI: 10.1084/jem.20050338.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, AntinuclearAntibody FormationAutoantigensAutoimmunityB-LymphocytesDNADNA-Binding ProteinsHumansImmunity, InnateLupus NephritisMembrane GlycoproteinsMiceMice, KnockoutReceptors, Cell SurfaceRibonucleoproteins, Small NuclearSnRNP Core ProteinsToll-Like Receptor 3Toll-Like Receptor 9Toll-Like ReceptorsConceptsToll-like receptor 9TLR9-deficient miceAutoantibody productionAutoimmune diseasesReceptor 9Clinical autoimmune diseaseDNA-containing antigensSelf-nuclear antigensAnti-DNA autoantibody productionAnti-dsDNA autoantibodiesLupus-prone miceSystemic lupus erythematosusFormation of autoantibodiesSystemic autoimmune diseaseInnate immune activationAutoreactive B cellsLupus erythematosusAutoantibody formationMurine lupusImmune activationImmunologic toleranceAntichromatin autoantibodiesSmith antigenCpG DNAB cells